Duman Hakan, Dilek Nursel, Değirmenci Hüsnü, Duman Handan, Tüfekçi Damla, Uslu Abdulkadir, Şatiroğlu Ömer, Çiçek Yüksel
Faculty of Medicine, Department of Cardiology, Recep Tayyip Erdoğan University, Rize, Turkey.
Faculty of Medicine, Department of Dermatology, Recep Tayyip Erdoğan University, Rize, Turkey.
Interv Med Appl Sci. 2018 Sep;10(3):150-156. doi: 10.1556/1646.10.2018.11.
Lichen planus (LP) carries the increased risk of cardiovascular events as it is a chronic inflammatory disease. This study aimed at determining the relationship between total atrial conduction time (TACT), P-wave dispersion, and the left atrium (LA) global strain in the patients with LP.
Forty people as a control group and 40 patients with LP were included in this study. Patient assessed global longitudinal LA strain by two-dimensional speckle-tracking strain echocardiography.
The global peak systolic LA myocardium strain during the left ventricular systole (LAGLSRs) and the global peak negative LA myocardial strain rate during the early ventricular diastole (LAGLSRe) values were significantly lower in the patients with LP in proportion to the control group according to the strain measurements (1.7 ± 0.07 vs. 1.9 ± 0.1%, = 0.001; 1.23 ± 0.04 vs. 1.2 ± 0.08 s, = 0.001), respectively. TACT value was found to be significantly longer (102.6 ± 6.3 ms) in the patients with LP than the control group (96.3 ± 5.3 ms, = 0.001), considering the terms of the artial conduction features.
This study demonstrated that the subclinical cardiac involvement in LP can determine the prolonged TACT and the impaired left atrial myocardial deformation values.
扁平苔藓（LP）作为一种慢性炎症性疾病，心血管事件风险增加。本研究旨在确定LP患者的全心房传导时间（TACT）、P波离散度与左心房（LA）整体应变之间的关系。
本研究纳入40名作为对照组的人员和40例LP患者。患者通过二维斑点追踪应变超声心动图评估左心房整体纵向应变。
根据应变测量结果，LP患者左心室收缩期左心房心肌整体峰值收缩应变（LAGLSRs）和心室舒张早期左心房心肌整体峰值负向应变率（LAGLSRe）值与对照组相比显著降低（分别为1.7±0.07%对1.9±0.1%，P = 0.001；1.23±0.04对1.2±0.08秒，P = 0.001）。从心房传导特征来看，LP患者的TACT值显著长于对照组（102.6±6.3毫秒对96.3±5.3毫秒，P = 0.001）。
本研究表明，LP患者的亚临床心脏受累可导致TACT延长和左心房心肌变形值受损。
