果蝇锌指蛋白CG9890与基因启动子上的染色质修饰和重塑复合物共定位，并参与转录调控。
Drosophila Zinc Finger Protein CG9890 Is Colocalized with Chromatin Modifying and Remodeling Complexes on Gene Promoters and Involved in Transcription Regulation.
作者信息
Fursova N A, Mazina M Y, Nikolenko J V, Vorobyova N E, Krasnov A N
机构信息
Institute of Gene Biology Russian Academy of Sciences, Moscow, 119334 Russia.
出版信息
Acta Naturae. 2020 Oct-Dec;12(4):114-119. doi: 10.32607/actanaturae.11056.
In this work, we conducted a genome-wide study of the zinc finger protein CG9890 and showed that it is localized mostly on the promoters of active genes. The CG9890 binding sites are low-nucleosome-density regions and are colocalized with the chromatin modifying and remodeling complexes SAGA and dSWI/SNF, as well as with the ORC replication complex. The CG9890 protein was shown to be involved in the regulation of the expression of some genes on the promoters of which it is located, with the ecdysone cascade genes accounting for a significant percentage of these genes. Thus, the CG9890 protein is a new member of the transcriptional network which is localized on active promoters, interacts with the main transcription and replication complexes, and is involved in the regulation of both basal and inducible transcription.
在本研究中，我们对锌指蛋白CG9890进行了全基因组研究，结果表明它主要定位于活跃基因的启动子上。CG9890的结合位点是低核小体密度区域，与染色质修饰和重塑复合物SAGA和dSWI/SNF以及ORC复制复合物共定位。研究表明，CG9890蛋白参与调控其所在启动子上一些基因的表达，其中蜕皮激素级联反应基因在这些基因中占相当大的比例。因此，CG9890蛋白是转录网络的一个新成员，它定位于活跃启动子上，与主要转录和复制复合物相互作用，并参与基础转录和诱导转录的调控。
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