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果蝇锌指蛋白CG9890与基因启动子上的染色质修饰和重塑复合物共定位，并参与转录调控。

Drosophila Zinc Finger Protein CG9890 Is Colocalized with Chromatin Modifying and Remodeling Complexes on Gene Promoters and Involved in Transcription Regulation.

作者信息

Fursova N A, Mazina M Y, Nikolenko J V, Vorobyova N E, Krasnov A N

机构信息

Institute of Gene Biology Russian Academy of Sciences, Moscow, 119334 Russia.

出版信息

Acta Naturae. 2020 Oct-Dec;12(4):114-119. doi: 10.32607/actanaturae.11056.

DOI:10.32607/actanaturae.11056
PMID:33456983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7800599/
Abstract

In this work, we conducted a genome-wide study of the zinc finger protein CG9890 and showed that it is localized mostly on the promoters of active genes. The CG9890 binding sites are low-nucleosome-density regions and are colocalized with the chromatin modifying and remodeling complexes SAGA and dSWI/SNF, as well as with the ORC replication complex. The CG9890 protein was shown to be involved in the regulation of the expression of some genes on the promoters of which it is located, with the ecdysone cascade genes accounting for a significant percentage of these genes. Thus, the CG9890 protein is a new member of the transcriptional network which is localized on active promoters, interacts with the main transcription and replication complexes, and is involved in the regulation of both basal and inducible transcription.

摘要

在本研究中，我们对锌指蛋白CG9890进行了全基因组研究，结果表明它主要定位于活跃基因的启动子上。CG9890的结合位点是低核小体密度区域，与染色质修饰和重塑复合物SAGA和dSWI/SNF以及ORC复制复合物共定位。研究表明，CG9890蛋白参与调控其所在启动子上一些基因的表达，其中蜕皮激素级联反应基因在这些基因中占相当大的比例。因此，CG9890蛋白是转录网络的一个新成员，它定位于活跃启动子上，与主要转录和复制复合物相互作用，并参与基础转录和诱导转录的调控。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88c0/7800599/8d7c4a08402f/AN20758251-12-04-114-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88c0/7800599/cf2b4bd10a80/AN20758251-12-04-114-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88c0/7800599/0557c44df84b/AN20758251-12-04-114-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88c0/7800599/68442499b785/AN20758251-12-04-114-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88c0/7800599/0b781316f3d7/AN20758251-12-04-114-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88c0/7800599/8d7c4a08402f/AN20758251-12-04-114-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88c0/7800599/cf2b4bd10a80/AN20758251-12-04-114-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88c0/7800599/0557c44df84b/AN20758251-12-04-114-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88c0/7800599/68442499b785/AN20758251-12-04-114-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88c0/7800599/0b781316f3d7/AN20758251-12-04-114-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88c0/7800599/8d7c4a08402f/AN20758251-12-04-114-g005.jpg

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本文引用的文献

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Zinc Finger Protein CG9890 - New Component of ENY2-Containing Complexes of Drosophila.锌指蛋白CG9890——果蝇含ENY2复合体的新组分。
Acta Naturae. 2018 Oct-Dec;10(4):110-114.
2
SAGA Is a General Cofactor for RNA Polymerase II Transcription.SAGA是RNA聚合酶II转录的通用辅因子。
Mol Cell. 2017 Oct 5;68(1):130-143.e5. doi: 10.1016/j.molcel.2017.08.016. Epub 2017 Sep 14.
3
ORC interacts with THSC/TREX-2 and its subunits promote Nxf1 association with mRNP and mRNA export in Drosophila.在果蝇中，ORC与THSC/TREX-2相互作用，其亚基促进Nxf1与mRNP结合以及mRNA输出。
Nucleic Acids Res. 2016 Jun 2;44(10):4920-33. doi: 10.1093/nar/gkw192. Epub 2016 Mar 25.
4
Early-late genes of the ecdysone cascade as models for transcriptional studies.蜕皮激素级联反应的早期-晚期基因作为转录研究的模型。
Cell Cycle. 2015;14(22):3593-601. doi: 10.1080/15384101.2015.1100772.
5
Drosophila Brahma complex remodels nucleosome organizations in multiple aspects.果蝇Brahma复合体在多个方面重塑核小体组织。
Nucleic Acids Res. 2014 Sep;42(15):9730-9. doi: 10.1093/nar/gku717. Epub 2014 Jul 31.
6
[Ability of Su(Hw) to create a platform for ORC binding does not depend on the type of surrounding chromatin].[Su(Hw) 创建 ORC 结合平台的能力不依赖于周围染色质的类型]
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7
Insulator protein Su(Hw) recruits SAGA and Brahma complexes and constitutes part of Origin Recognition Complex-binding sites in the Drosophila genome.绝缘子蛋白 Su(Hw) 招募 SAGA 和 Brahma 复合物，并构成果蝇基因组中识别复合物结合位点的一部分。
Nucleic Acids Res. 2013 Jun;41(11):5717-30. doi: 10.1093/nar/gkt297. Epub 2013 Apr 22.
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The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila.DUBm 亚基 Sgf11 对于 mRNA 输出是必需的，并与果蝇中的 Cbp80 相互作用。
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SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation.SAYP 与 DHR3 核受体相互作用，并参与蜕皮激素依赖性转录调控。
Cell Cycle. 2011 Jun 1;10(11):1821-7. doi: 10.4161/cc.10.11.15727.
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Chromatin signatures of the Drosophila replication program.果蝇复制程序的染色质特征。
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