Department of Chemistry, Faculty of Science, Cairo University, 12613 Giza, Egypt.
National Gene Bank of Egypt (NGB), Agricultural Research Center (ARC), Giza, Egypt.
Biomed Res Int. 2019 Jan 1;2019:2698570. doi: 10.1155/2019/2698570. eCollection 2019.
Moringa grows in the tropical and subtropical regions of the world. The genus belongs to family Moringaceae. It is found to possess various medicinal uses including hypoglycemic, analgesic, anti-inflammatory, hypolipidemic, and antioxidant activities. In this study, we investigated the antimicrobial and the anticancer activity of the as well as leaves extracts grown locally in Egypt. Results indicated that most of the extracts were found to possess high antimicrobial activity against gram-positive bacteria, gram-negative bacteria, and fungus. The survival rate of cancer cells was decreased in both hepatocellular carcinoma (HepG2) and breast carcinoma (MCF-7) cell lines when treated with leaves extracts. In addition, the cell cycle progression, apoptosis, and cancer-related genes confirmed its anticancer effect. The toxicity of each extract was also tested using the normal melanocytes cell line HFB4. The toxicity was low in both and leaves extracts. Furthermore, GC/MS analysis fractionized the phytochemicals content for each potential extract. In conclusion, results suggested that the and leaves extracts possess antimicrobial and anticancer properties which could be attributed to the bioactive phytochemical compounds present inside the extracts from this plant. These findings can be used to develop new drugs, especially for liver cancer chemotherapy.
辣木生长在世界的热带和亚热带地区。该属属于辣木科。它被发现具有各种药用用途，包括降血糖、镇痛、抗炎、降血脂和抗氧化活性。在这项研究中，我们研究了在埃及当地生长的辣木叶和根提取物的抗菌和抗癌活性。结果表明，大多数提取物对革兰氏阳性菌、革兰氏阴性菌和真菌具有很高的抗菌活性。用辣木叶提取物处理肝癌（HepG2）和乳腺癌（MCF-7）细胞系时，癌细胞的存活率降低。此外，细胞周期进程、细胞凋亡和与癌症相关的基因证实了其抗癌作用。还使用正常黑素细胞系 HFB4 测试了每种提取物的毒性。根和叶提取物的毒性都很低。此外，GC/MS 分析对每个潜在提取物的植物化学成分进行了分段。总之，结果表明，辣木叶和根提取物具有抗菌和抗癌特性，这可能归因于该植物提取物中存在的生物活性植物化学成分。这些发现可用于开发新的药物，特别是用于肝癌化疗。
