Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering , South China University of Technology , Guangzhou 510640 , P. R. China.
Org Lett. 2019 Feb 15;21(4):1125-1129. doi: 10.1021/acs.orglett.9b00072. Epub 2019 Feb 4.
The first iridium-catalyzed three-component coupling reaction of carbon dioxide, amines, and sulfoxonium ylides has been developed, providing an efficient and straightforward method for the construction of a range of structurally diverse O-β-oxoalkyl carbamates in moderate to excellent yields. This novel protocol features the use of readily available substrates, wide substrate scope, and good functional group tolerance. Moreover, the phosgene-free strategy was successfully applied to the synthesis of a potential antitumor agent.
首次发展了二氧化碳、胺和亚砜叶立德的铱催化的三组分偶联反应，为构建一系列结构多样的 O-β-氧代烷基氨基甲酸酯提供了一种高效、直接的方法，产率中等至优秀。该新方法具有使用易得的底物、宽底物范围和良好的官能团耐受性的特点。此外，成功地将无光气策略应用于潜在抗肿瘤剂的合成中。
