1 Department of Physiology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
2 College of Medicine, University of Illinois, IL 60612, USA.
Exp Biol Med (Maywood). 2019 Feb;244(2):83-99. doi: 10.1177/1535370219828195. Epub 2019 Feb 2.
Cancer is among the leading causes of death worldwide. In 2016, 8.9 million people are estimated to have died from various forms of cancer. The current treatments, including surgery with chemotherapy and/or radiation therapy, are not effective enough to provide full protection from cancer, which highlights the need for developing novel therapy strategies. In this review, we summarize the molecular biology of a unique member of a subfamily of receptor tyrosine kinase, TYRO3 and discuss the new insights in TYRO3-targeted treatment for cancer therapy.
癌症是全球主要死因之一。2016 年，估计有 890 万人死于各种形式的癌症。目前的治疗方法，包括手术结合化疗和/或放射治疗，不足以提供对癌症的充分保护，这突出了开发新的治疗策略的必要性。在这篇综述中，我们总结了受体酪氨酸激酶亚家族中一个独特成员 TYRO3 的分子生物学，并讨论了针对 TYRO3 的治疗方法在癌症治疗中的新见解。
