School of Chemistry and Chemical Engineering , University of Jinan , Jinan 250022 , China.
Natural Products Research Center, Chengdu Institute of Biology , Chinese Academy of Sciences , Chengdu , Sichuan 610041 , China.
ACS Appl Mater Interfaces. 2019 Feb 27;11(8):7725-7730. doi: 10.1021/acsami.8b19658. Epub 2019 Feb 14.
Bacterial infection, especially multidrug-resistant (MDR) bacteria-induced wound infection, is an enormous challenge and is the result of the inability of traditional antibiotics to combat MDR bacteria produced by the abuse of broad-spectrum drugs. Here, we present multivalent aminosaccharide-based gold nanoparticles (AuNPs) to remedy the superbug-infected wound. We synthesized multivalent aminosaccharide-based AuNPs via a straightforward method using d-glucosamine (GluN) to modify gold nanoparticles (AuNPs) as reported. This kind of multivalent aminosaccharide-based AuNP (Au_GluN) can lower the bacterial viability in a mature biofilm that may lead to antibiotic resistance. Au_GluN is innocuous not only for erythrocytes in vitro but also for mice. Moreover, it displays an outstanding ability for superbug-infected wound healing. Such a material provides new candidates to treat bacteria in the clinic.
细菌感染，特别是多重耐药（MDR）细菌引起的伤口感染，是一个巨大的挑战，这是由于传统抗生素无法对抗由滥用广谱药物产生的 MDR 细菌。在这里，我们提出了基于多价氨基糖的金纳米粒子（AuNPs）来补救超级细菌感染的伤口。我们通过一种简单的方法合成了基于多价氨基糖的 AuNPs，使用 D-葡糖胺（GluN）来修饰金纳米粒子（AuNPs），正如报道的那样。这种基于多价氨基糖的 AuNP（Au_GluN）可以降低成熟生物膜中细菌的活力，从而导致抗生素耐药性。Au_GluN 不仅对体外的红细胞无害，对小鼠也无害。此外，它对超级细菌感染的伤口愈合具有出色的能力。这种材料为临床治疗细菌提供了新的候选药物。
