Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Sciences , China Agricultural University , Beijing 100193 , China.
Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience , National Center for NanoScience and Technology , No. 11 Zhongguancun Beiyitiao , Beijing 100190 , P. R. China.
ACS Appl Mater Interfaces. 2018 Sep 5;10(35):29398-29406. doi: 10.1021/acsami.8b11980. Epub 2018 Aug 22.
We synthesize indole derivative-capped gold nanoparticles (Au_IDs) via a straightforward route to fight multidrug-resistant (MDR) bacteria. When gold nanoparticles are modified with two indole derivatives, tryptophan and 5-aminoindole, they exhibit excellent antibacterial activities against both laboratory antibiotic-sensitive and MDR bacteria. Au_IDs possess remarkable bactericidal activities against MDR bacteria killing 99.9% of MDR Escherichia coli and polymyxin-resistant Klebsiella pneumoniae after 0.5 h of incubation, which are superior to clinical antibiotics including polymyxin B and cefotaxime. By evaluating the potential of Au_IDs in wound cure, Au_IDs show outstanding capability in MDR bacterial wound infection. Our findings provide new candidates for the development of bactericides and the fabrication of wound dressings for treating MDR infection.
我们通过一种简单的方法合成了吲哚衍生物封端的金纳米粒子（Au_IDs），以对抗多药耐药（MDR）细菌。当金纳米粒子被两种吲哚衍生物色氨酸和 5-氨基吲哚修饰时，它们对实验室抗生素敏感和 MDR 细菌均表现出优异的抗菌活性。Au_IDs 对 MDR 细菌具有显著的杀菌活性，在孵育 0.5 小时后，能杀死 99.9%的多粘菌素耐药大肠杆菌和多粘菌素耐药肺炎克雷伯菌，优于包括多粘菌素 B 和头孢噻肟在内的临床抗生素。通过评估 Au_IDs 在伤口愈合方面的潜力，Au_IDs 在治疗 MDR 细菌感染的伤口方面表现出了出色的能力。我们的研究结果为开发杀菌剂和制造治疗 MDR 感染的伤口敷料提供了新的候选物。
