肌肉干细胞：骨科领域有哪些新进展？
Muscle stem cells: what's new in orthopedics?
作者信息
Biz Carlo, Crimi Alberto, Fantoni Ilaria, Pozzuoli Assunta, Ruggieri Pietro
机构信息
Orthopaedic Clinic, Department of Surgery, Oncology and Gastroenterology DiSCOG, University of Padua, Padova, Italy.
出版信息
Acta Biomed. 2019 Jan 25;90(1-S):8-13. doi: 10.23750/abm.v90i1-S.8078.
BACKGROUND AND AIM OF THE WORK
Adult stem cells were studied as a source of potentially useful development for tissue engineering and repair techniques. The aim of this review is to clarify the actual and possible uses of muscle stem cells in orthopedics.
METHODS
A selection of studies was made to obtain a homogeneous and up to date overview on the muscle stem cells applications.
RESULTS
In recent years muscle was studied as a good source of adult stem cells that can differentiate into different cell lineages. Muscle stem cells are a heterogeneous population of cells, which demonstrated in vitro a great potential for the regeneration and repair of muscle, bone and cartilage tissue. Among muscle stem cells, satellite stem cells are the most known progenitor cells: they can differentiate in osteoblasts, adipocytes, chondrocytes and myocytes.
CONCLUSIONS
Although muscle stem cells are a promising field of research, more pre-clinical studies in animal models are still needed to determine the safety and efficiency of the transplant procedures in humans.
工作背景与目的
研究成体干细胞作为组织工程和修复技术潜在有用发育来源的情况。本综述的目的是阐明肌肉干细胞在骨科中的实际及可能用途。
方法
进行了一系列研究以获取关于肌肉干细胞应用的统一且最新的概述。
结果
近年来，肌肉被视为成体干细胞的良好来源，这些干细胞可分化为不同细胞谱系。肌肉干细胞是异质性细胞群体，在体外显示出对肌肉、骨骼和软骨组织进行再生和修复的巨大潜力。在肌肉干细胞中，卫星干细胞是最为人所知的祖细胞：它们可分化为成骨细胞、脂肪细胞、软骨细胞和肌细胞。
结论
尽管肌肉干细胞是一个有前景的研究领域，但仍需要在动物模型中进行更多临床前研究，以确定在人体中移植程序的安全性和有效性。
Zotero 插件