Biz Carlo, Crimi Alberto, Fantoni Ilaria, Pozzuoli Assunta, Ruggieri Pietro
Orthopaedic Clinic, Department of Surgery, Oncology and Gastroenterology DiSCOG, University of Padua, Padova, Italy.
Acta Biomed. 2019 Jan 25;90(1-S):8-13. doi: 10.23750/abm.v90i1-S.8078.
Adult stem cells were studied as a source of potentially useful development for tissue engineering and repair techniques. The aim of this review is to clarify the actual and possible uses of muscle stem cells in orthopedics.
A selection of studies was made to obtain a homogeneous and up to date overview on the muscle stem cells applications.
In recent years muscle was studied as a good source of adult stem cells that can differentiate into different cell lineages. Muscle stem cells are a heterogeneous population of cells, which demonstrated in vitro a great potential for the regeneration and repair of muscle, bone and cartilage tissue. Among muscle stem cells, satellite stem cells are the most known progenitor cells: they can differentiate in osteoblasts, adipocytes, chondrocytes and myocytes.
Although muscle stem cells are a promising field of research, more pre-clinical studies in animal models are still needed to determine the safety and efficiency of the transplant procedures in humans.
研究成体干细胞作为组织工程和修复技术潜在有用发育来源的情况。本综述的目的是阐明肌肉干细胞在骨科中的实际及可能用途。
进行了一系列研究以获取关于肌肉干细胞应用的统一且最新的概述。
近年来，肌肉被视为成体干细胞的良好来源，这些干细胞可分化为不同细胞谱系。肌肉干细胞是异质性细胞群体，在体外显示出对肌肉、骨骼和软骨组织进行再生和修复的巨大潜力。在肌肉干细胞中，卫星干细胞是最为人所知的祖细胞：它们可分化为成骨细胞、脂肪细胞、软骨细胞和肌细胞。
尽管肌肉干细胞是一个有前景的研究领域，但仍需要在动物模型中进行更多临床前研究，以确定在人体中移植程序的安全性和有效性。
