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重庆市交通警察体内邻苯二甲酸酯类和性激素水平及其可能来源。

Levels of phthalate acid esters and sex hormones and their possible sources in traffic-patrol policemen in Chongqing.

机构信息

Department of Health Education, Army Medical University (Third Military Medical University), Chongqing, China.

Academic Affairs of Army Medical University (Third Military Medical University), Chongqing, China.

出版信息

Environ Sci Pollut Res Int. 2019 Mar;26(9):9005-9013. doi: 10.1007/s11356-019-04265-4. Epub 2019 Feb 4.

Abstract

To investigate the correlation between the air phthalate acid ester (PAE) exposure and serum PAE concentration and the effects of PAE exposure on reproductive health among Chongqing traffic-patrol policemen. In 2013, 32 traffic-patrol policemen working in an area with poor air quality in Chongqing and 28 traffic-patrol policemen working in an area with good air quality were selected. Their blood levels of 14 PAEs and six reproductive hormones were determined. Air samples were collected from four traffic-patrol platforms. The concentrations of 14 PAEs in the air samples were evaluated. All 14 PAEs were detected in the blood samples. The concentrations of seven PAEs in the total suspended particulate, namely, dimethyl phthalate, diethyl phthalate, dibutyl phthalate, bis (2-ethox-yethyl) phthalate, dihexyl phthalate, benzyl butyl phthalate, and bis (2-n-butoxyethyl) phthalate, were positively and significantly associated with the blood levels of these PAEs in the participants. All the sex hormone levels measured here were significantly different between the participants from the two areas. The PAE concentrations in the blood samples were correlated with the reproductive hormone levels in the participants. Air PAE pollution may be a major source of PAE exposure in the traffic-patrol policemen of Chongqing.

摘要

目的 探讨重庆市交通警察体内邻苯二甲酸酯(PAE)暴露与血清 PAE 浓度的相关性,以及 PAE 暴露对其生殖健康的影响。方法 2013 年选择重庆市空气质量较差地区和空气质量较好地区各 32 名交通警察,采集其血样和空气样本,检测血样中 14 种 PAE 和 6 种生殖激素水平,评估空气样本中 14 种 PAE 的浓度。结果 血样中均检测到 14 种 PAE,其中 7 种 PAE(邻苯二甲酸二甲酯、邻苯二甲酸二乙酯、邻苯二甲酸二丁酯、邻苯二甲酸二(2-乙氧基)乙酯、邻苯二甲酸二己酯、邻苯二甲酸丁基苄基酯和邻苯二甲酸二(2-正丁氧基)乙酯)在空气中的浓度与交通警察血中相应 PAE 浓度呈正相关。两组交通警察体内的各项生殖激素水平均存在显著差异。交通警察血中 PAE 浓度与生殖激素水平相关。结论 重庆交通警察体内 PAE 暴露可能主要来自于空气 PAE 污染。

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