• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

增塑剂邻苯二甲酸二丁酯（DBP）损害妊娠血管健康：对钙信号传导和一氧化氮参与情况的见解。

The Plasticizer Dibutyl Phthalate (DBP) Impairs Pregnancy Vascular Health: Insights into Calcium Signaling and Nitric Oxide Involvement.

作者信息

Quelhas Ana R, Mariana Melissa, Cairrao Elisa

机构信息

RISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal.

FCS-UBI, Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilhã, Portugal.

出版信息

J Xenobiot. 2025 Aug 6;15(4):127. doi: 10.3390/jox15040127.

DOI:10.3390/jox15040127
PMID:40863334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12387933/
Abstract

Dibutyl phthalate (DBP) is used as a plasticizer to enhance flexibility in several household products, cosmetics, and food-contact materials. Due to its harmful effects, DBP is restricted or banned in children's products and food items, particularly in Europe. Due to its endocrine disruptor properties and considering its ability to cross the placental barrier, it is imperative to study DBP's vascular effects in pregnancy, given the vulnerability of this period. Thus, this study investigated the potential effects of DBP on the cardiovascular system using umbilical arteries from healthy pregnant women. Specifically, the impact of DBP on the vascular reactivity after both rapid and 24 h DBP exposure was analyzed, as well as the contractility and the cell viability of vascular smooth muscle cells (VSMC). DBP did not exhibit overt cytotoxic effects on VSMCs, possibly due to its adsorption onto polystyrene surfaces, potentially limiting bioavailability. Interestingly, DBP induced vasorelaxation in a concentration-dependent manner. Although mechanistic insights remain to be fully elucidated, the results suggest the involvement of pathways associated with nitric oxide signaling and calcium handling. Overall, DBP exposure appears to modulate arterial tone regulation, which may have implications for vascular function during pregnancy.

摘要

邻苯二甲酸二丁酯（DBP）用作增塑剂，以增强多种家用产品、化妆品和食品接触材料的柔韧性。由于其有害影响，DBP在儿童产品和食品中受到限制或禁止，尤其是在欧洲。鉴于其内分泌干扰特性，并考虑到其穿越胎盘屏障的能力，鉴于孕期的脆弱性，研究DBP在孕期对血管的影响势在必行。因此，本研究使用健康孕妇的脐动脉，研究了DBP对心血管系统的潜在影响。具体而言，分析了快速和24小时DBP暴露后DBP对血管反应性的影响，以及血管平滑肌细胞（VSMC）的收缩性和细胞活力。DBP对VSMC未表现出明显的细胞毒性作用，这可能是由于其吸附在聚苯乙烯表面，可能限制了生物利用度。有趣的是，DBP以浓度依赖的方式诱导血管舒张。尽管机制仍有待充分阐明，但结果表明与一氧化氮信号传导和钙处理相关的途径参与其中。总体而言，DBP暴露似乎会调节动脉张力调节，这可能对孕期血管功能有影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/7089d4958e54/jox-15-00127-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/7233488ba70f/jox-15-00127-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/406cf0fec3d8/jox-15-00127-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/1bd7b0583e50/jox-15-00127-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/8ed2d410b3c6/jox-15-00127-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/8f40644de4cd/jox-15-00127-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/1babb4139bb9/jox-15-00127-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/fddc11824819/jox-15-00127-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/e24eebbc5baa/jox-15-00127-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/be972e062fe1/jox-15-00127-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/5a01fa8ddd8d/jox-15-00127-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/a796c870d9a7/jox-15-00127-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/7089d4958e54/jox-15-00127-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/7233488ba70f/jox-15-00127-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/406cf0fec3d8/jox-15-00127-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/1bd7b0583e50/jox-15-00127-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/8ed2d410b3c6/jox-15-00127-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/8f40644de4cd/jox-15-00127-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/1babb4139bb9/jox-15-00127-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/fddc11824819/jox-15-00127-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/e24eebbc5baa/jox-15-00127-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/be972e062fe1/jox-15-00127-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/5a01fa8ddd8d/jox-15-00127-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/a796c870d9a7/jox-15-00127-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70af/12387933/7089d4958e54/jox-15-00127-g012.jpg

相似文献

1
The Plasticizer Dibutyl Phthalate (DBP) Impairs Pregnancy Vascular Health: Insights into Calcium Signaling and Nitric Oxide Involvement.增塑剂邻苯二甲酸二丁酯（DBP）损害妊娠血管健康：对钙信号传导和一氧化氮参与情况的见解。
J Xenobiot. 2025 Aug 6;15(4):127. doi: 10.3390/jox15040127.
2
Prescription of Controlled Substances: Benefits and Risks管制药品的处方：益处与风险
3
Synergies of dibutyl phthalate on high-fat diet can aggravate cardiac fibrosis/dysfunction and the protective effects of vitamin E and salidroside: A molecular toxicological study in Sprague-Dawley rats.邻苯二甲酸二丁酯对高脂饮食的协同作用可加重心脏纤维化/功能障碍以及维生素E和红景天苷的保护作用：一项在Sprague-Dawley大鼠中的分子毒理学研究
Ecotoxicol Environ Saf. 2025 Jul 19;302:118708. doi: 10.1016/j.ecoenv.2025.118708.
4
Elbow Fractures Overview肘部骨折概述
5
Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy.干预影响一氧化氮通路与安慰剂或无治疗妊娠胎儿生长受限。
Cochrane Database Syst Rev. 2023 Jul 10;7(7):CD014498. doi: 10.1002/14651858.CD014498.
6
Management of urinary stones by experts in stone disease (ESD 2025).结石病专家对尿路结石的管理（2025年结石病专家共识）
Arch Ital Urol Androl. 2025 Jun 30;97(2):14085. doi: 10.4081/aiua.2025.14085.
7
Inhaled nitric oxide for treating pain crises in people with sickle cell disease.吸入一氧化氮治疗镰状细胞病患者的疼痛危象。
Cochrane Database Syst Rev. 2022 Jul 8;7(7):CD011808. doi: 10.1002/14651858.CD011808.pub3.
8
Electrochemical bioplatform for the determination of the most common and carcinogenic dibutyl phthalate migrated from daily-use plastic products.用于测定从日常塑料制品中迁移出的最常见致癌物质邻苯二甲酸二丁酯的电化学生物平台。
Mikrochim Acta. 2025 Aug 1;192(8):548. doi: 10.1007/s00604-025-07418-0.
9
Effectiveness and safety of vitamin D in relation to bone health.维生素D对骨骼健康的有效性与安全性。
Evid Rep Technol Assess (Full Rep). 2007 Aug(158):1-235.
10
Epidural therapy for the treatment of severe pre-eclampsia in non labouring women.硬膜外治疗非分娩期妇女的重度子痫前期。
Cochrane Database Syst Rev. 2017 Nov 28;11(11):CD009540. doi: 10.1002/14651858.CD009540.pub2.

本文引用的文献

1
Endocrine Disrupting Toxicity of Bisphenol A and Its Analogs: Implications in the Neuro-Immune Milieu.双酚A及其类似物的内分泌干扰毒性：对神经免疫环境的影响
J Xenobiot. 2025 Jan 17;15(1):13. doi: 10.3390/jox15010013.
2
Prenatal Exposure to Dibutyl Phthalate and Its Negative Health Effects on Offspring: In Vivo and Epidemiological Studies.产前暴露于邻苯二甲酸二丁酯及其对后代的负面健康影响：体内和流行病学研究
J Xenobiot. 2024 Dec 19;14(4):2039-2075. doi: 10.3390/jox14040109.
3
Polyphenols Regulate the Activity of Endocrine-Disrupting Chemicals, Having Both Positive and Negative Effects.
多酚调节内分泌干扰化学物质的活性，具有正负两方面的影响。
J Xenobiot. 2024 Oct 2;14(4):1378-1405. doi: 10.3390/jox14040077.
4
Phthalate exposure during pregnancy and its association with thyroid hormones: A prospective cohort study.孕期邻苯二甲酸酯暴露及其与甲状腺激素的关系：一项前瞻性队列研究。
Int J Hyg Environ Health. 2024 Aug;261:114421. doi: 10.1016/j.ijheh.2024.114421. Epub 2024 Jul 13.
5
Vascular endothelial effects of dibutyl phthalate: In vitro and in vivo evidence.邻苯二甲酸二丁酯的血管内皮效应：体外和体内证据。
Chem Biol Interact. 2024 Aug 25;399:111120. doi: 10.1016/j.cbi.2024.111120. Epub 2024 Jun 28.
6
Exposure to DEP Modifies the Human Umbilical Artery Vascular Resistance Contributing to Hypertension in Pregnancy.接触柴油机废气颗粒会改变人脐动脉血管阻力，进而导致妊娠期高血压。
J Xenobiot. 2024 Apr 18;14(2):497-515. doi: 10.3390/jox14020030.
7
Lycium barbarum polysaccharides attenuate oxidative stress and mitochondrial toxicity induced by mixed plasticizers in HepG2 cells through activation of Nrf2.枸杞多糖通过激活 Nrf2 减轻混合增塑剂诱导的 HepG2 细胞氧化应激和线粒体毒性。
Life Sci. 2024 Jan 1;336:122346. doi: 10.1016/j.lfs.2023.122346. Epub 2023 Dec 10.
8
Methodological challenges in using human umbilical artery as a model for in vitro studies.利用人脐动脉作为体外研究模型的方法学挑战。
Exp Physiol. 2023 Dec;108(12):1569-1578. doi: 10.1113/EP091374. Epub 2023 Oct 14.
9
Adverse cardiovascular effects of long-term exposure to diethyl phthalate in the rat aorta.长期暴露于邻苯二甲酸二乙酯对大鼠主动脉产生的不良心血管影响。
Chemosphere. 2023 Nov;340:139904. doi: 10.1016/j.chemosphere.2023.139904. Epub 2023 Aug 21.
10
Phthalates' exposure leads to an increasing concern on cardiovascular health.邻苯二甲酸酯的暴露引起了人们对心血管健康越来越多的关注。
J Hazard Mater. 2023 Sep 5;457:131680. doi: 10.1016/j.jhazmat.2023.131680. Epub 2023 May 23.