降钙素基因相关肽与血管紧张素II在血压及肾素释放方面的相互作用。

The interaction of calcitonin gene-related peptide with angiotensin II on blood pressure and renin release.

作者信息

Itabashi A, Kashiwabara H, Shibuya M, Tanaka K, Masaoka H, Katayama S, Ishii J

机构信息

Fourth Department of Medicine, Saitama Medical School, Japan.

出版信息

J Hypertens Suppl. 1988 Dec;6(4):S418-20. doi: 10.1097/00004872-198812040-00131.

DOI:10.1097/00004872-198812040-00131

PMID:3071580

Abstract

Calcitonin gene-related peptide (CGRP) has been shown to be a potent vasorelaxant. We tested the interaction of CGRP with angiotensin II (Ang II) in conscious, unrestrained Wistar rats. Rat CGRP (rCGRP, 0.1 and 1.0 nmol/kg per min) dose-dependently lowered mean arterial blood pressure and increased the heart rate. The effects continued throughout the infusion period of 30 min. Moreover, rCGRP significantly attenuated the pressor responses to Ang II (100 ng/kg per min). High-dose rCGRP (1.0 nmol/kg per min) almost abolished the pressor action of Ang II, and a much higher dose of Ang II (1000 ng/kg per min) was needed to restore the pre-infusion pressure. Plasma renin activity was dose-dependently increased by rCGRP, but was attenuated by simultaneous Ang II infusion. Rat CGRP also increased the plasma aldosterone concentration, as did Ang II. These results suggest that CGRP may have a neuromodulatory role in cardiovascular regulation.

摘要

降钙素基因相关肽（CGRP）已被证明是一种强效血管舒张剂。我们在清醒、不受束缚的Wistar大鼠中测试了CGRP与血管紧张素II（Ang II）的相互作用。大鼠CGRP（rCGRP，每分钟0.1和1.0 nmol/kg）剂量依赖性地降低平均动脉血压并增加心率。这些作用在30分钟的输注期内持续存在。此外，rCGRP显著减弱了对Ang II（每分钟100 ng/kg）的升压反应。高剂量rCGRP（每分钟1.0 nmol/kg）几乎消除了Ang II的升压作用，需要更高剂量的Ang II（每分钟1000 ng/kg）才能恢复输注前的血压。rCGRP使血浆肾素活性呈剂量依赖性增加，但同时输注Ang II可使其减弱。大鼠CGRP也增加了血浆醛固酮浓度，Ang II也是如此。这些结果表明，CGRP可能在心血管调节中具有神经调节作用。