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实验进化揭示了微生物与宿主肠道共生的特征。

Experimental evolution reveals microbial traits for association with the host gut.

机构信息

Department of Biology, Emory University, Atlanta, Georgia, United States of America.

出版信息

PLoS Biol. 2019 Feb 4;17(2):e3000129. doi: 10.1371/journal.pbio.3000129. eCollection 2019 Feb.

DOI:10.1371/journal.pbio.3000129
PMID:30716061
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6375648/
Abstract

Understanding how microbes adapt to their host is an enduring problem in microbiome ecology, and understanding the microbial traits that allow colonization of the host and increase adaptation to the host environment is of particular interest. In this study, Robinson and colleagues use experimental evolution to demonstrate adaptation of a commensal bacterium to its zebrafish host and describe the changes in phenotype that emerge during this evolutionary process. These results provide insight into the evolutionary problem of host adaptation and demonstrate the utility of simple models for understanding host-microbiome dynamics.

摘要

了解微生物如何适应其宿主是微生物组生态学中的一个持久问题,而了解允许微生物定植宿主并增加对宿主环境适应的微生物特征则特别有趣。在这项研究中,Robinson 及其同事使用实验进化来证明一种共生细菌对其斑马鱼宿主的适应性,并描述了在这个进化过程中出现的表型变化。这些结果为宿主适应的进化问题提供了深入了解,并展示了简单模型在理解宿主-微生物组动态方面的实用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe75/6375648/d253b7a2170a/pbio.3000129.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe75/6375648/d253b7a2170a/pbio.3000129.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe75/6375648/d253b7a2170a/pbio.3000129.g001.jpg

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2
Bacterial Cohesion Predicts Spatial Distribution in the Larval Zebrafish Intestine.细菌的黏附性决定了其在斑马鱼幼虫肠道中的空间分布。
Biophys J. 2018 Dec 4;115(11):2271-2277. doi: 10.1016/j.bpj.2018.10.017. Epub 2018 Oct 30.
3
Modernized Tools for Streamlined Genetic Manipulation and Comparative Study of Wild and Diverse Proteobacterial Lineages.
宿主发育在控制斑马鱼肠道微生物组的生态演替中压倒环境扩散。
NPJ Biofilms Microbiomes. 2021 Jan 19;7(1):5. doi: 10.1038/s41522-020-00176-2.
用于简化遗传操作和比较研究野生和多样变形杆菌谱系的现代化工具。
mBio. 2018 Oct 9;9(5):e01877-18. doi: 10.1128/mBio.01877-18.
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Emergent simplicity in microbial community assembly.微生物群落组装中的紧急简化。
Science. 2018 Aug 3;361(6401):469-474. doi: 10.1126/science.aat1168.
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Bacterial Adaptation to the Host's Diet Is a Key Evolutionary Force Shaping Drosophila-Lactobacillus Symbiosis.细菌对宿主饮食的适应是塑造果蝇-乳酸菌共生关系的关键进化力量。
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