Reynolds E H
Maudsley Hospital, London.
Jpn J Psychiatry Neurol. 1988 Sep;42(3):429-35. doi: 10.1111/j.1440-1819.1988.tb01333.x.
In the last decade community and hospital-based studies of epilepsy from the onset of the disorder have revealed a much more favorable prognosis for seizure control than previously reported. Approximately three-quarters of newly diagnosed patients can enter a prolonged remission on currently available medication. The natural history of untreated epilepsy is unknown but there is some evidence of an escalating process in the early stages in patients with tonic-clonic seizures. The first two years of treatment seem to be important in determining the subsequent course of epilepsy. The longer seizures continue, the less likely they are to be controlled. Early effective treatment may be important in preventing the evolution of chronic epilepsy. These observations have implications for the management of patients with single seizures.
在过去十年中，基于社区和医院对癫痫从发病开始的研究表明，与之前报道相比，癫痫发作控制的预后要好得多。大约四分之三新诊断的患者使用目前可用的药物可进入长期缓解期。未经治疗的癫痫的自然病程尚不清楚，但有一些证据表明，强直阵挛性发作患者在早期阶段存在病情进展过程。治疗的头两年似乎对决定癫痫的后续病程很重要。癫痫发作持续的时间越长，就越难得到控制。早期有效治疗对于预防慢性癫痫的发展可能很重要。这些观察结果对单次发作患者的管理具有重要意义。
