Reynolds E H
Department of Neurology, Maudsley Hospital, London, England.
Epilepsia. 1988;29 Suppl 1:S25-8. doi: 10.1111/j.1528-1157.1988.tb05788.x.
Recent epidemiological and hospital-based studies of newly diagnosed epileptic patients suggest that the prognosis for epilepsy is much more favourable than had previously been reported and believed. Approximately three-quarters of such patients may expect to go into prolonged remission with currently available drugs, utilised as monotherapy. For chronic epileptic patients, however, the outlook for seizure control is poor. Factors that contribute to the development of chronic epilepsy are partial or multiple seizure types, brain pathology, neuropsychiatric or social handicaps, poor compliance, and the early response to treatment. Evidence is presented that epilepsy should be viewed as a process in which early effective treatment may be important to prevent the evolution of chronic epilepsy, which is so difficult to control.
近期对新诊断癫痫患者的流行病学和基于医院的研究表明,癫痫的预后比之前报道和认为的要好得多。大约四分之三的此类患者有望通过目前可用的药物作为单一疗法实现长期缓解。然而,对于慢性癫痫患者来说,控制癫痫发作的前景不佳。导致慢性癫痫发展的因素包括部分或多种发作类型、脑部病变、神经精神或社会障碍、依从性差以及对治疗的早期反应。有证据表明,癫痫应被视为一个过程,在此过程中早期有效治疗对于预防难以控制的慢性癫痫的发展可能很重要。