Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia 97, 95125 Catania, Italy.
Department of Drug Sciences, University of Catania, Viale Andrea Doria, 6, 95125 Catania, Italy.
Int J Mol Sci. 2019 Feb 1;20(3):634. doi: 10.3390/ijms20030634.
Ozone therapy has been widely used in everyday clinical practice over the last few years, leading to significant clinical results in the treatment of herniated discs and pain management. Nevertheless, further studies have demonstrated its potential efficacy and safety under other clinical and experimental conditions. However, some of these studies showed controversial results regarding the safety and efficacy of ozone therapy, thus mining its potential use in an everyday clinical practice. To this regard, it should be considered that extensive literature review reported the use of ozone in a significant different dose range and with different delivery systems. The aim of the present review is to describe the various pharmacological effects of ozone in different organs and clinical conditions and to provide possible biochemical and molecular insights for ozone biological properties, thus providing a possible explanation for various controversial clinical outcomes described in the scientific literature.
臭氧治疗在过去几年中已广泛应用于临床实践，在治疗椎间盘突出症和疼痛管理方面取得了显著的临床效果。然而，进一步的研究表明，在其他临床和实验条件下，臭氧也具有潜在的疗效和安全性。然而，其中一些研究表明臭氧治疗的安全性和疗效存在争议，因此需要挖掘其在日常临床实践中的潜在用途。在这方面，应该考虑到广泛的文献综述报告了臭氧在显著不同的剂量范围和不同的输送系统中的使用。本综述的目的是描述臭氧在不同器官和临床情况下的各种药理作用，并为臭氧的生物学特性提供可能的生化和分子见解，从而为科学文献中描述的各种有争议的临床结果提供可能的解释。
