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用于生物分析应用的结构化磁性金属纳米片的简易制备

Simple Fabrication of Structured Magnetic Metallic Nano-Platelets for Bio-Analytical Applications.

作者信息

Novotny Jakub, Juskova Petra, Kupcik Rudolf, Bilkova Zuzana, Foret Frantisek

机构信息

Institute of Analytical Chemistry of the Czech Academy of Sciences, Veveri 967/97, 602 00 Brno, Czech Republic.

Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic.

出版信息

Micromachines (Basel). 2019 Feb 3;10(2):106. doi: 10.3390/mi10020106.

DOI:10.3390/mi10020106
PMID:30717443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6412862/
Abstract

This short communication presents a simple method of preparation of thin-metal nano-platelets utilizing metal sputtering and lift-off photolithography. The method offers complete control over size, shape and properties of nano-platelets of sub-micrometer thickness. Platelets with a thickness of 50⁻200 nm and with defined arbitrary shapes and sizes in the range of 15⁻300 μm were prepared from single or multiple metal layers by magnetron sputtering. Deposition of different metals in layers enabled fabrication of bi- or tri-metallic platelets with a magnetic core and differently composed surfaces. Highly reflective nano-platelets with a magnetic core allowed manipulation by magnetic fields, while different metallic surfaces served for functionalization by selected molecules. Submicron thin nano-platelets are extremely light (e.g., ~20 ng for a 100 μm × 100 μm × 0.1 μm gold nano-platelet) so that they can be attached to surfaces by only a few chemical bonds. At the same time their area is sufficiently large for simple optical recognition of their shape which is intended to label various characteristics depending on the specific surface functionalization of the given shape.

摘要

本简短通讯介绍了一种利用金属溅射和剥离光刻技术制备薄金属纳米片的简单方法。该方法能完全控制亚微米厚度纳米片的尺寸、形状和性能。通过磁控溅射从单层或多层金属制备出厚度为50-200nm、形状和尺寸在15-300μm范围内任意确定的薄片。分层沉积不同金属能够制造出具有磁芯和不同组成表面的双金属或三金属薄片。具有磁芯的高反射纳米片可通过磁场进行操控,而不同的金属表面可用于特定分子的功能化。亚微米薄纳米片极其轻(例如,对于100μm×100μm×0.1μm的金纳米片约为20ng),因此它们仅通过少数化学键就能附着到表面。同时,它们的面积足够大,便于简单光学识别其形状,旨在根据给定形状的特定表面功能化来标记各种特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c980/6412862/53871285bd0f/micromachines-10-00106-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c980/6412862/b59b3d12907e/micromachines-10-00106-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c980/6412862/df6d5ba09687/micromachines-10-00106-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c980/6412862/e75548ab09a2/micromachines-10-00106-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c980/6412862/53871285bd0f/micromachines-10-00106-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c980/6412862/b59b3d12907e/micromachines-10-00106-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c980/6412862/df6d5ba09687/micromachines-10-00106-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c980/6412862/e75548ab09a2/micromachines-10-00106-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c980/6412862/53871285bd0f/micromachines-10-00106-g004.jpg

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