Yoshida M, Tanaka M
Department of Pharmacology, Kurume University School of Medicine, Japan.
Neurosci Lett. 1988 Nov 22;94(1-2):5-9. doi: 10.1016/0304-3940(88)90261-3.
The present study revealed existence of a new dopaminergic nerve terminal plexus in the rat spinal cord, which was visualized by means of the peroxidase antiperoxidase immunohistochemical technique utilizing antibody prepared against conjugated dopamine. Dopamine (DA)-immunoreactive nerve terminals occurred along the ventral motor column throughout all spinal levels, as well as previously noted presumed dopaminergic nerve terminals within the intermediolateral cell column, the dorsal horn and in the area surrounding the central canal. In these new terminals of the anterior column, fine DA-immunoreactive nerve terminals concentrated around motoneurons, suggesting that the dopaminergic nerve system may also be involved in somatic motor processes of the spinal cord.
本研究揭示了大鼠脊髓中存在一种新的多巴胺能神经终末丛，该神经终末丛通过使用针对结合多巴胺制备的抗体的过氧化物酶抗过氧化物酶免疫组织化学技术得以显现。多巴胺（DA）免疫反应性神经终末存在于整个脊髓节段的腹侧运动柱，以及先前在中间外侧细胞柱、背角和中央管周围区域发现的推测为多巴胺能的神经终末。在前柱的这些新终末中，细小的DA免疫反应性神经终末集中在运动神经元周围，提示多巴胺能神经系统可能也参与脊髓的躯体运动过程。
