Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan.
Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
BMC Complement Altern Med. 2019 Feb 4;19(1):42. doi: 10.1186/s12906-019-2446-3.
There are no published studies regarding the efficacy of traditional Chinese medicine (TCM) for the prevention of osteoporotic fracture. Therefore, we conducted this nationwide, population-based cohort study to investigate the probable effect of TCM to decrease the fracture rate.
We identified cases with osteoporosis and selected a comparison group that was frequency-matched according to sex, age (per 5 years), diagnosis year of osteoporosis, and index year. The difference between the two groups in the development of fracture was estimated using the Kaplan-Meier method and the log-rank test.
After inserting age, gender, urbanization level, and comorbidities into the Cox's proportional hazard model, patients who used TCM had a lower hazard ratio (HR) of fracture (adjusted HR: 0.47, 95% CI: 0.37-0.59) compared to the non-TCM user group. The Kaplan-Meier curves showed that osteoporosis patients who used TCM had a lower incidence of fracture events than those who did not (p < 0.00001). Our study also demonstrated that the longer the TCM use, the lesser the fracture rate.
Our study showed that TCM might have a positive impact on the prevention of osteoporotic fracture.
目前尚无关于中医药预防骨质疏松性骨折疗效的研究。因此，我们进行了这项全国性、基于人群的队列研究，以探讨中医药预防骨折的可能效果。
我们确定了患有骨质疏松症的病例，并选择了一个根据性别、年龄（每 5 年）、骨质疏松症诊断年份和指数年份进行频率匹配的对照组。使用 Kaplan-Meier 方法和对数秩检验估计两组之间骨折发展的差异。
在将年龄、性别、城市化水平和合并症纳入 Cox 比例风险模型后，与非中医药使用者相比，使用中医药的患者骨折的风险比（调整后的 HR：0.47，95%CI：0.37-0.59）较低。Kaplan-Meier 曲线表明，使用中医药的骨质疏松症患者的骨折事件发生率低于未使用中医药的患者（p<0.00001）。我们的研究还表明，中医药使用时间越长，骨折发生率越低。
我们的研究表明，中医药可能对预防骨质疏松性骨折有积极影响。
