Ochi Hirofumi
Department of Neurology and Geriatric Medicine, Ehime University Graduate School of Medicine.
Brain Nerve. 2019 Feb;71(2):143-152. doi: 10.11477/mf.1416201233.
Multiple sclerosis (MS) is a complex immune-mediated disease of the central nervous system. It is characterized by inflammatory and neurodegenerative processes that result in progressive neurological disability. In the past two decades, there have been major therapeutic advances in the treatment of MS, and a substantial number of disease-modifying drugs (DMDs) have been used in clinical practice. The currently available DMDs are effective in controlling inflammatory activity, but not neurodegenerative processes. In such cases, non-pharmacological approaches such as exercise therapy may play an important role. Although patients with MS were traditionally advised not to participate in physical activity, there is growing evidence that exercise therapy has potential disease-modifying anti-inflammatory and neuroprotective effects in patients with MS. This article reviews previous studies on the general benefits of exercise therapy and provides an overview of the current knowledge regarding the theoretical background of exercise therapy in patients with MS.
多发性硬化症（MS）是一种复杂的中枢神经系统免疫介导疾病。其特征是炎症和神经退行性变过程，导致进行性神经功能残疾。在过去二十年中，MS治疗取得了重大进展，大量疾病修正药物（DMDs）已应用于临床实践。目前可用的DMDs在控制炎症活动方面有效，但对神经退行性变过程无效。在这种情况下，运动疗法等非药物方法可能发挥重要作用。尽管传统上建议MS患者不要参加体育活动，但越来越多的证据表明，运动疗法对MS患者具有潜在的疾病修正抗炎和神经保护作用。本文回顾了先前关于运动疗法总体益处的研究，并概述了目前关于MS患者运动疗法理论背景的知识。
