Rahimibarghani Sarvenaz, Azadvari Mohaddeseh, Emami-Razavi Seyede Zahra, Harirchian Mohammad Hossein, Rahimi-Dehgolan Shahram, Fateh Hamid R
Physical Medicine and Rehabilitation Department (SR, MA, SZE-R, SR-D, HRF), Tehran University of Medical Sciences, Tehran, Iran.
Iranian Center of Neurological Research, Neuroscience Institute (MHH), Tehran University of Medical Sciences, Tehran, Iran.
Int J MS Care. 2022 Sep-Oct;24(5):202-208. doi: 10.7224/1537-2073.2021-004. Epub 2022 Jun 22.
Exercise has been demonstrated to be safe and well-tolerated in individuals with multiple sclerosis (MS). Physical activity has been shown to enhance the therapeutic effects of transcranial direct current stimulation (tDCS). This study aimed to determine the efficacy of intermittent tDCS combined with riding a stationary bicycle to improve walking capacity in individuals with MS.
This double-blind randomized controlled trial enrolled 50 eligible participants. Thirty-nine participants completed the study: 21 in the active group and 18 in the control group. Participants were assigned randomly to exercise on a stationary bike in conjunction with anodal tDCS or to exercise combined with a sham tDCS protocol. Walking capacity tests (2-Minute Walk Test, 5-Meter Walk Test, Timed Up and Go test), manual muscle testing, the Fatigue Severity Scale, and the Multiple Sclerosis Quality of Life-54 were used to determine outcomes.
In terms of observed changes in 2-Minute Walk Test and 5-Meter Walk Test values, the exercise + tDCS group achieved significantly higher posttreatment values than the exercise + sham tDCS group. After the intervention and 1 month later, the intervention group's mean Timed Up and Go test value decreased significantly ( = .002) compared with that of the control group. There was no difference in Fatigue Severity Scale score, Multiple Sclerosis Quality of Life-54 score, or manual muscle testing improvement between the 2 groups.
Nonconsecutive sessions of anodal tDCS combined with stationary cycling may have a greater effect on the walking capacity of individuals with MS than exercise alone.
运动已被证明对多发性硬化症（MS）患者是安全且耐受性良好的。体育活动已被证明可增强经颅直流电刺激（tDCS）的治疗效果。本研究旨在确定间歇性tDCS联合骑固定自行车对改善MS患者步行能力的疗效。
这项双盲随机对照试验招募了50名符合条件的参与者。39名参与者完成了研究：21名在活性组，18名在对照组。参与者被随机分配接受阳极tDCS联合在固定自行车上锻炼，或接受假tDCS方案联合锻炼。采用步行能力测试（2分钟步行测试、5米步行测试、计时起立行走测试）、徒手肌力测试、疲劳严重程度量表和多发性硬化症生活质量-54来确定结果。
就2分钟步行测试和5米步行测试值的观察变化而言，锻炼+tDCS组的治疗后值显著高于锻炼+假tDCS组。干预后及1个月后，干预组的平均计时起立行走测试值与对照组相比显著降低（P = 0.002）。两组在疲劳严重程度量表评分、多发性硬化症生活质量-54评分或徒手肌力测试改善方面无差异。
非连续 sessions of阳极tDCS联合固定自行车骑行对MS患者步行能力的影响可能比单独锻炼更大。
