Centre for Brain and Cognitive Development, Birkbeck College, University of London, London, WC1E 7HX, United Kingdom.
Autism Research Laboratory, Moscow State University of Psychology and Education, Moscow, Russia.
Transl Psychiatry. 2019 Feb 4;9(1):66. doi: 10.1038/s41398-019-0380-2.
We conducted a replication study of our prior report that increased alpha EEG connectivity at 14-months associates with later autism spectrum disorder (ASD) diagnosis, and dimensional variation in restricted interests/repetitive behaviours. 143 infants at high and low familial risk for ASD watched dynamic videos of spinning toys and women singing nursery rhymes while high-density EEG was recorded. Alpha functional connectivity (7-8 Hz) was calculated using the debiased weighted phase lag index. The final sample with clean data included low-risk infants (N = 20), and high-risk infants who at 36 months showed either typical development (N = 47), atypical development (N = 21), or met criteria for ASD (N = 13). While we did not replicate the finding that global EEG connectivity associated with ASD diagnosis, we did replicate the association between higher functional connectivity at 14 months and greater severity of restricted and repetitive behaviours at 36 months in infants who met criteria for ASD. We further showed that this association is strongest for the circumscribed interests subdomain. We propose that structural and/or functional abnormalities in frontal-striatal circuits underlie the observed association. This is the first replicated infant neural predictor of dimensional variation in later ASD symptoms.
我们对之前的报告进行了复制研究，该报告表明，14 个月时α脑电连接增加与后来的自闭症谱系障碍（ASD）诊断以及受限兴趣/重复行为的维度变化有关。143 名具有高和低 ASD 家族风险的婴儿观看旋转玩具和女性唱童谣的动态视频，同时记录高密度 EEG。使用无偏加权相位滞后指数计算α功能连接（7-8 Hz）。具有清洁数据的最终样本包括低风险婴儿（N=20）和高风险婴儿，这些婴儿在 36 个月时表现出典型发育（N=47）、非典型发育（N=21）或符合 ASD 标准（N=13）。虽然我们没有复制与 ASD 诊断相关的全局 EEG 连接的发现，但我们确实复制了在符合 ASD 标准的婴儿中，14 个月时功能连接较高与 36 个月时受限和重复行为严重程度较高之间的关联。我们进一步表明，这种关联在限定性兴趣子域中最强。我们提出，额叶-纹状体回路的结构和/或功能异常是观察到的关联的基础。这是第一个复制的婴儿神经预测因子，用于预测后来 ASD 症状的维度变化。
