van Nijnatten T J A, Smidt M L, Goorts B, Samiei S, Houben I, Kok E M, Wildberger J E, Robben S G F, Lobbes M B I
Department of Radiology and Nuclear Medicine, Maastricht University Medical Center+, Maastricht, the Netherlands.
Department of Surgery, Maastricht University Medical Center+, Maastricht, the Netherlands.
J Cancer. 2019 Jan 1;10(3):765-771. doi: 10.7150/jca.30494. eCollection 2019.
To investigate whether full-field digital mammography (FFDM) and contrast-enhanced mammography (CEM), evaluated by non-experienced high school students, improves detection of missed breast cancer lesions on FFDM, in the same cohort of patients. Non-experienced first- and second year high school students examined fourteen cases of patients diagnosed with breast cancer. These cases consisted of missed breast cancer lesions on FFDM by a breast radiologist. Sensitivity of assessment of the students on FFDM and CEM was analysed and compared with the initial results of the breast radiologists. A total of 134 high school students participated in this study. Mean age was 12.8 years (range 10-14). Based on FFDM, mean overall sensitivity of the students was 29.2% (18.9 - 39.6%). When recombined CEM images were used, mean overall sensitivity of students improved to 82.6% (74.0 - 91.2%) (p=0.001). Mean overall sensitivity of FFDM exams evaluated by radiologists was 75.7% (64.2 - 87.3%), which was lower when compared to student's evaluations on recombined CEM exams, yet not statistically significant (p=0.098). Contrast-enhanced mammography evaluated by non-experienced high school students might improve detection rate of breast cancer when compared to evaluations of only full-field digital mammography by radiologists.
为了调查在同一组患者中，由没有经验的高中生评估的全视野数字乳腺摄影（FFDM）和对比增强乳腺摄影（CEM）是否能提高FFDM上漏诊的乳腺癌病灶的检出率。没有经验的高一和高二学生检查了14例被诊断为乳腺癌的患者病例。这些病例包括乳腺放射科医生在FFDM上漏诊的乳腺癌病灶。分析了学生对FFDM和CEM评估的敏感性，并与乳腺放射科医生的初始结果进行了比较。共有134名高中生参与了这项研究。平均年龄为12.8岁（范围10 - 14岁）。基于FFDM，学生的平均总体敏感性为29.2%（18.9 - 39.6%）。当使用重组CEM图像时，学生的平均总体敏感性提高到82.6%（74.0 - 91.2%）（p = 0.001）。放射科医生评估的FFDM检查的平均总体敏感性为75.7%（64.2 - 87.3%），与学生对重组CEM检查的评估相比更低，但无统计学意义（p = 0.098）。与仅由放射科医生进行全视野数字乳腺摄影评估相比，由没有经验的高中生评估的对比增强乳腺摄影可能会提高乳腺癌的检出率。
