Kawaguchi Yoshihiro, Kimura Shoichi, Momozono Kosuke, Igawa Tsukasa, Noguchi Masanori
Department of Urology, Omuta City Hospital, Omuta, Japan.
Department of Urology, Kurume University School of Medicine, Kurume, Japan.
Rare Tumors. 2019 Jan 22;11:2036361318825165. doi: 10.1177/2036361318825165. eCollection 2019.
Lymphoma of the urinary bladder is uncommon, and upper urinary tract obstruction due to lymphoma is rare. Herein, we report a case of malignant lymphoma of the bladder with bilateral hydronephrosis in a 67-year-old female who presented with oliguria. Ultrasonography and computed tomography demonstrated a thickened posterior bladder wall and bilateral hydronephrosis. Whole-body positron emission tomography-computed tomography revealed abnormal accumulation in the right iliac internal lymph nodes. Trans-urethral bladder biopsy led to a histopathological diagnosis of non-Hodgkin diffuse large B-cell malignant lymphoma of the bladder. After bilateral nephrostomy, the patient was treated with six cycles of combination chemotherapy including rituximab, cyclophosphamide, daunorubicin, vincristine, and prednisolone (R-CHOP) and two cycles of rituximab alone. Complete remission was maintained during the 3 years of follow-up.
膀胱淋巴瘤并不常见，由淋巴瘤导致的上尿路梗阻则更为罕见。在此，我们报告一例67岁女性膀胱恶性淋巴瘤合并双侧肾积水的病例，该患者表现为少尿。超声检查和计算机断层扫描显示膀胱后壁增厚及双侧肾积水。全身正电子发射断层扫描-计算机断层扫描显示右髂内淋巴结有异常聚集。经尿道膀胱活检得出膀胱非霍奇金弥漫大B细胞恶性淋巴瘤的组织病理学诊断。双侧肾造瘘术后，患者接受了六个周期的联合化疗，包括利妥昔单抗、环磷酰胺、柔红霉素、长春新碱和泼尼松龙（R-CHOP），以及两个周期的单纯利妥昔单抗治疗。在3年的随访期间维持了完全缓解。
