INKA Intelligente Katheter, Otto-von-Guericke-Universität Magdeburg, Magdenurg, Germany.
J Healthc Eng. 2019 Jan 3;2019:2784516. doi: 10.1155/2019/2784516. eCollection 2019.
The efficiency of electroporation (EP) has made it a widely used therapeutic procedure to transfer cell killing substances effectively to the target site. A lot of researches are being done on EP-based cancer treatment techniques. Electrochemotherapy (ECT) is the first EP-based application in the field of drug administration. ECT is a local and nonthermal treatment of cancer that combines the use of a medical device with pharmaceutical agents to obtain local tumor control in solid cancers. It involves the application of eight, 100s, pulses at 1 or 5000 Hz frequency and specified electric field (V/cm) with a median duration of 25 minutes. The efficacy of chemotherapeutic drugs increases by applying short and intense electrical pulses. Several clinical studies proposed ECT as a safe and complementary curative or palliative treatment option (curative intent of 50% to 63% in the treatment of Basal Cell Carcinoma (BCC)) to treat a number of solid tumors and skin malignancies, which are not suitable for conventional treatments. It is used currently for treatment of cutaneous and subcutaneous lesions, without consideration of their histology. On the contrary, it is also becoming a practical method for treatment of internal, deep-seated tumors and tissues. A review of this method, needed instruments, alternative image-guided procedures (IGP) approaches, and future perspectives and recommendations are discussed in this paper.
电穿孔（EP）的效率使其成为一种将细胞杀伤物质有效传递到靶位的广泛应用的治疗程序。许多研究都在进行基于 EP 的癌症治疗技术。电化学疗法（ECT）是药物管理领域中第一个基于 EP 的应用。ECT 是一种局部和非热治疗癌症的方法，它将医疗设备与药物联合使用，以获得实体癌中的局部肿瘤控制。它涉及在 25 分钟的中位数持续时间内应用八个、100 个、1 或 5000 Hz 频率的脉冲和指定的电场（V/cm）。应用短而强烈的电脉冲可提高化疗药物的疗效。几项临床研究提出 ECT 是一种安全且互补的治疗或姑息治疗选择（治疗基底细胞癌（BCC）的 50%至 63%的治疗意图），以治疗许多不适合传统治疗的实体肿瘤和皮肤恶性肿瘤。目前，它用于治疗皮肤和皮下病变，而不考虑其组织学。相反，它也正在成为治疗内部、深部肿瘤和组织的实用方法。本文讨论了这种方法、所需仪器、替代图像引导程序（IGP）方法以及未来的观点和建议。
