Department of Physiology, Chhattisgarh Institute of Medical Sciences, Bilaspur, India.
Department of Anatomy, Chhattisgarh Institute of Medical Sciences, Bilaspur, India.
J Membr Biol. 2024 Dec;257(5-6):281-305. doi: 10.1007/s00232-024-00323-2. Epub 2024 Aug 25.
Electrophysiology typically deals with the electrical properties of excitable cells like neurons and muscles. However, all other cells (non-excitable) also possess bioelectric membrane potentials for intracellular and extracellular communications. These membrane potentials are generated by different ions present in fluids available in and outside the cell, playing a vital role in communication and coordination between the cell and its organelles. Bioelectric membrane potential variations disturb cellular ionic homeostasis and are characteristic of many diseases, including cancers. A rapidly increasing interest has emerged in sorting out the electrophysiology of cancer cells. Compared to healthy cells, the distinct electrical properties exhibited by cancer cells offer a unique way of understanding cancer development, migration, and progression. Decoding the altered bioelectric signals influenced by fluctuating electric fields benefits understanding cancer more closely. While cancer research has predominantly focussed on genetic and molecular traits, the delicate area of electrophysiological characteristics has increasingly gained prominence. This review explores the historical exploration of electrophysiology in the context of cancer cells, shedding light on how alterations in bioelectric membrane potentials, mediated by ion channels and gap junctions, contribute to the pathophysiology of cancer.
电生理学通常涉及神经元和肌肉等可兴奋细胞的电学特性。然而，所有其他细胞（非兴奋细胞）也具有生物电膜电位，用于细胞内和细胞外的通讯。这些膜电位是由细胞内外可用的流体中的不同离子产生的，在细胞与其细胞器之间的通讯和协调中起着至关重要的作用。生物电膜电位的变化扰乱了细胞的离子动态平衡，是许多疾病（包括癌症）的特征。人们对癌症细胞的电生理学进行分类的兴趣迅速增加。与健康细胞相比，癌细胞表现出的独特电学特性为了解癌症的发展、迁移和进展提供了一种独特的方法。解析受波动电场影响的生物电信号有助于更深入地了解癌症。虽然癌症研究主要集中在遗传和分子特征上，但电生理学特性这一微妙领域的重要性日益凸显。本综述探讨了电生理学在癌细胞背景下的历史探索，阐明了离子通道和缝隙连接介导的生物电膜电位变化如何导致癌症的病理生理学变化。
