• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

序列变异对 rRNA 进化的影响。

Implications of sequence variation on the evolution of rRNA.

机构信息

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.

Department of Immunology, Weill Cornell Medicine, New York, NY, USA.

出版信息

Chromosome Res. 2019 Mar;27(1-2):89-93. doi: 10.1007/s10577-018-09602-w. Epub 2019 Feb 5.

DOI:10.1007/s10577-018-09602-w
PMID:30719681
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6505490/
Abstract

The evolution of the multi-copy family of ribosomal RNA (rRNA) genes is unique in regard to its genetics and genome evolution. Paradoxically, rRNA genes are highly homogenized within and between individuals, yet they are globally distinct between species. Here, we discuss the implications for models of rRNA gene evolution in light of our recent discoveries that ribosomes bearing rRNA sequence variants can affect gene expression and physiology and that intra-individual rRNA alleles exhibit both context- and tissue-specific expression.

摘要

核糖体 RNA(rRNA) 基因的多拷贝家族的进化在其遗传学和基因组进化方面是独特的。矛盾的是，rRNA 基因在个体内部和个体之间高度同质化，但在物种之间却具有全球性差异。在这里，我们根据最近的发现讨论了 rRNA 基因进化模型的意义，这些发现表明携带 rRNA 序列变体的核糖体可以影响基因表达和生理，并且个体内的 rRNA 等位基因表现出组织和上下文特异性表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7399/6505490/0642499a9e87/10577_2018_9602_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7399/6505490/0642499a9e87/10577_2018_9602_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7399/6505490/0642499a9e87/10577_2018_9602_Fig1_HTML.jpg

相似文献

1
Implications of sequence variation on the evolution of rRNA.序列变异对 rRNA 进化的影响。
Chromosome Res. 2019 Mar;27(1-2):89-93. doi: 10.1007/s10577-018-09602-w. Epub 2019 Feb 5.
2
Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression.变异核糖体 RNA 等位基因是保守的，并表现出组织特异性表达。
Sci Adv. 2018 Feb 28;4(2):eaao0665. doi: 10.1126/sciadv.aao0665. eCollection 2018 Feb.
3
Sequence variation within the rRNA gene loci of 12 Drosophila species.12种果蝇物种核糖体RNA基因位点内的序列变异。
Genome Res. 2007 Dec;17(12):1888-97. doi: 10.1101/gr.6376807. Epub 2007 Nov 7.
4
Two-dimensional RFLP analyses reveal megabase-sized clusters of rRNA gene variants in Arabidopsis thaliana, suggesting local spreading of variants as the mode for gene homogenization during concerted evolution.二维限制性片段长度多态性分析揭示了拟南芥中核糖体RNA基因变异体的兆碱基大小的簇，这表明变异体的局部扩散是协同进化过程中基因同质化的模式。
Plant J. 1996 Feb;9(2):273-82. doi: 10.1046/j.1365-313x.1996.09020273.x.
5
Contrasting evolutionary patterns of 28S and ITS rRNA genes reveal high intragenomic variation in Cephalenchus (Nematoda): Implications for species delimitation.28S和ITS rRNA基因的对比进化模式揭示了头线虫属（线虫纲）的高基因组内变异：对物种界定的影响
Mol Phylogenet Evol. 2016 May;98:244-60. doi: 10.1016/j.ympev.2016.02.016. Epub 2016 Feb 27.
6
The ribosomal RNA genes of Tetrahymena: structure and function.四膜虫的核糖体RNA基因：结构与功能。
Eur J Cell Biol. 1985 Jan;36(1):133-51.
7
Gene conversion drives within genic sequences: concerted evolution of ribosomal RNA genes in bacteria and archaea.基因序列内的基因转换驱动：细菌和古菌核糖体RNA基因的协同进化。
J Mol Evol. 2000 Oct;51(4):305-17. doi: 10.1007/s002390010093.
8
Diversity of ribosomes at the level of rRNA variation associated with human health and disease.核糖体在 rRNA 变异水平上的多样性与人类健康和疾病有关。
Cell Genom. 2024 Sep 11;4(9):100629. doi: 10.1016/j.xgen.2024.100629. Epub 2024 Aug 6.
9
Concerted evolution of ribosomal DNA: Somatic peace amid germinal strife: Intranuclear and cellular selection maintain the quality of rRNA.核糖体 DNA 的协同进化：生殖冲突中的体细胞和平：核内和细胞选择维持 rRNA 的质量。
Bioessays. 2021 Dec;43(12):e2100179. doi: 10.1002/bies.202100179. Epub 2021 Oct 27.
10
The ribosome as a missing link in prebiotic evolution II: Ribosomes encode ribosomal proteins that bind to common regions of their own mRNAs and rRNAs.核糖体作为生命起源前进化中的关键环节II：核糖体编码与自身mRNA和rRNA的共同区域结合的核糖体蛋白。
J Theor Biol. 2016 May 21;397:115-27. doi: 10.1016/j.jtbi.2016.02.030. Epub 2016 Mar 4.

引用本文的文献

1
Assessing Human Ribosomal DNA Variation and Its Association With Phenotypic Outcomes.评估人类核糖体DNA变异及其与表型结果的关联。
Bioessays. 2025 Apr;47(4):e202400232. doi: 10.1002/bies.202400232. Epub 2025 Jan 20.
2
The Importance of Being RNA-est: considering RNA-mediated ribosome plasticity.重视 RNA 调节：考虑 RNA 介导的核糖体可塑性。
RNA Biol. 2023 Jan;20(1):177-185. doi: 10.1080/15476286.2023.2204581.
3
First discovered, long out of sight, finally visible: ribosomal DNA.最初被发现，长期不见踪影，最终可见：核糖体 DNA。

本文引用的文献

1
Endogenous rRNA Sequence Variation Can Regulate Stress Response Gene Expression and Phenotype.内源性 rRNA 序列变异可调节应激反应基因表达和表型。
Cell Rep. 2018 Oct 2;25(1):236-248.e6. doi: 10.1016/j.celrep.2018.08.093.
2
Translation: The Universal Structural Core of Life.生命的普遍结构核心。
Mol Biol Evol. 2018 Aug 1;35(8):2065-2076. doi: 10.1093/molbev/msy101.
3
Long reads: their purpose and place.长读序列：它们的用途和位置。
Trends Genet. 2022 Jun;38(6):587-597. doi: 10.1016/j.tig.2022.02.005.
4
Identification of Abundant and Functional dodecaRNAs (doRNAs) Derived from Ribosomal RNA.鉴定源于核糖体 RNA 的丰富且具有功能的十二聚 RNA (doRNAs)。
Int J Mol Sci. 2021 Sep 9;22(18):9757. doi: 10.3390/ijms22189757.
5
Inhibition of the Eukaryotic 80S Ribosome as a Potential Anticancer Therapy: A Structural Perspective.从结构角度看，抑制真核生物80S核糖体作为一种潜在的抗癌疗法。
Cancers (Basel). 2021 Aug 31;13(17):4392. doi: 10.3390/cancers13174392.
6
Analysis of Acanthamoeba genotypes from public freshwater sources in Thailand reveals a new genotype, T23 Acanthamoeba bangkokensis sp. nov.分析泰国公共淡水中棘阿米巴的基因型，发现一种新的基因型，即 T23 棘阿米巴曼谷种。
Sci Rep. 2021 Aug 27;11(1):17290. doi: 10.1038/s41598-021-96690-0.
7
The role of internal transcribed spacer 2 secondary structures in classifying mycoparasitic Ampelomyces.内转录间隔区 2 二级结构在分类菌寄生菌拟青霉中的作用。
PLoS One. 2021 Jun 30;16(6):e0253772. doi: 10.1371/journal.pone.0253772. eCollection 2021.
8
Age-Dependent and Tissue-Specific Alterations in the rDNA Clusters of the C. A. Meyer Cultivated Cell Lines.年龄相关和组织特异性改变在 C. A. Meyer 培养细胞系的 rDNA 簇中。
Biomolecules. 2020 Oct 6;10(10):1410. doi: 10.3390/biom10101410.
9
Unambiguous identification of fungi: where do we stand and how accurate and precise is fungal DNA barcoding?真菌的明确鉴定：我们目前的状况如何，真菌DNA条形码技术的准确性和精确性如何？
IMA Fungus. 2020 Jul 10;11:14. doi: 10.1186/s43008-020-00033-z. eCollection 2020.
10
The Utility of Graph Clustering of 5S Ribosomal DNA Homoeologs in Plant Allopolyploids, Homoploid Hybrids, and Cryptic Introgressants.5S核糖体DNA同源基因的图谱聚类在植物异源多倍体、同倍体杂种和隐性渐渗系中的应用
Front Plant Sci. 2020 Feb 10;11:41. doi: 10.3389/fpls.2020.00041. eCollection 2020.
Hum Mol Genet. 2018 Aug 1;27(R2):R234-R241. doi: 10.1093/hmg/ddy177.
4
Heterogeneity and specialized functions of translation machinery: from genes to organisms.翻译机器的异质性和专门功能：从基因到生物体。
Nat Rev Genet. 2018 Jul;19(7):431-452. doi: 10.1038/s41576-018-0008-z.
5
Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression.变异核糖体 RNA 等位基因是保守的，并表现出组织特异性表达。
Sci Adv. 2018 Feb 28;4(2):eaao0665. doi: 10.1126/sciadv.aao0665. eCollection 2018 Feb.
6
Highly divergent 16S rRNA sequences in ribosomal operons of Scytonema hyalinum (Cyanobacteria).透明颤藻（蓝细菌）核糖体操纵子中高度分化的16S rRNA序列。
PLoS One. 2017 Oct 26;12(10):e0186393. doi: 10.1371/journal.pone.0186393. eCollection 2017.
7
Eukaryotic ribosome assembly, transport and quality control.真核生物核糖体的组装、运输和质量控制。
Nat Struct Mol Biol. 2017 Sep 7;24(9):689-699. doi: 10.1038/nsmb.3454.
8
The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity.哺乳动物核糖体相互作用组揭示了核糖体功能的多样性和异质性。
Cell. 2017 Jun 1;169(6):1051-1065.e18. doi: 10.1016/j.cell.2017.05.022.
9
Detecting non-allelic homologous recombination from high-throughput sequencing data.从高通量测序数据中检测非等位基因同源重组
Genome Biol. 2015 Apr 8;16(1):72. doi: 10.1186/s13059-015-0633-1.
10
Evolution of the ribosome at atomic resolution.原子分辨率下核糖体的进化。
Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10251-6. doi: 10.1073/pnas.1407205111. Epub 2014 Jun 30.