Key Laboratory of Preventive Veterinary Medicine and Biotechnology, Longyan University,Longyan 364012, China.
Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases andBiotechnology, Longyan University, Longyan 364012, China.
Molecules. 2019 Feb 4;24(3):563. doi: 10.3390/molecules24030563.
Inflammation is related to many diseases. Lindera akoensis Hayata was often used in folktherapy in Taiwan for inflammation. In this study, three new flavonol acyl glycosides, namelykaempferol-3-O--D-4",6"-di-(E)-p-coumaroylglucoside (1), 3"-(E)-p-coumaroylafzelin (2) and 40-Omethyl-2",4"-di-(E)-p-coumaroylquercitrin (3), and three components, 3-dodecyl-4-hydroxy-5-methyldihydrofuran-2-one (4), 2-acetoxyclovan-9-ol (5), (1,4,6)-trihydroxyeudesmane(6) that were isolated from the natural product for the first time were obtained along with 25 knowncompounds from L. akoensis. Their structures were determined by comprehensive spectroscopicanalyses (1D and 2D NMR, EI-, ESI- and HRESI-MS). The ability of 1 to decrease the LPS-stimulatedproduction of nitrite in RAW264.7 cell was evaluated, showing an IC value of 36.3 ± 3.2 μM.This result supports the value of L. akoensis as a traditional medicine resource.
炎症与许多疾病有关。台湾民间疗法常使用乌药来治疗炎症。在这项研究中，从乌药中分离得到了三种新的黄酮醇酰基糖苷，即山奈酚-3-O--D-4",6"-二-(E)-对香豆酰基葡萄糖苷（1）、3"-(E)-对香豆酰基芹菜素（2）和 40-O-甲基-2",4"-二-(E)-对香豆酰基槲皮苷（3），以及三种首次从天然产物中分离得到的成分，3-十二烷基-4-羟基-5-甲基二氢呋喃-2-酮（4）、2-乙酰氧基环戊烷-9-醇（5）、(1,4,6)-三羟基- 穗木烷（6）。它们的结构通过综合光谱分析（1D 和 2D NMR、EI、ESI 和 HRESI-MS）确定。评估了 1 降低 LPS 刺激 RAW264.7 细胞中亚硝酸盐产生的能力，结果显示其 IC 值为 36.3±3.2 μM。这一结果支持了乌药作为传统医学资源的价值。
