从山胡椒的地上部分中分离得到的一种新的丁内酯化合物，具有抗炎活性。
A new butanolide compound from the aerial part of Lindera akoensis with anti-inflammatory activity.
机构信息
School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan.
出版信息
Molecules. 2012 May 31;17(6):6585-92. doi: 10.3390/molecules17066585.
A new butanolide, 3β-((E)-dodec-1-enyl)-4β-hydroxy-5β-methyldihydrofuran-2-one (1) and four known butanolides: Akolactone A (2), (3Z,4α,5β)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (3), (3E,4α,5β)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (4) and dihydroisoobtusilactone (5), were isolated from the aerial parts of Lindera akoensis. These butanolides showed in vitro anti-inflammatory activity decrease the LPS-stimulated production of nitrite in RAW264.7 cell, with IC₅₀ values of 1.4-179.9 μM.
从山鸡椒 Lindera akoensis 的地上部分分离得到一种新的丁内酯化合物 3β-((E)-十二烯-1-基)-4β-羟基-5β-甲基二氢呋喃-2-酮（1）和四种已知的丁内酯化合物：阿克内酯 A（2）、(3Z,4α,5β)-3-(十二烯-11-亚基)-4-羟基-5-甲基丁内酯（3）、(3E,4α,5β)-3-(十二烯-11-亚基)-4-羟基-5-甲基丁内酯（4）和二氢异缬草酸内酯（5）。这些丁内酯化合物表现出体外抗炎活性，降低 LPS 刺激的 RAW264.7 细胞中亚硝酸盐的产生，IC₅₀ 值为 1.4-179.9 μM。
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