Department of Physical Chemistry, Unviersity of Madras, Guindy Campus, Chennai 600 025, India.
Faculty of Engineering, Department of Mechanical Engineering, University of Tarapacá, Avda. General Velásquez 1775, Arica, Chile.
J Colloid Interface Sci. 2019 Apr 15;542:45-53. doi: 10.1016/j.jcis.2019.01.118. Epub 2019 Jan 29.
The detection of water soluble vitamins using electrochemical method is widely established in pharmaceutical quality control laboratories, and especially the recent advances in hybrid heterostrucure nanomaterials has devoted to enhance the significant analytical parameters like sensitivity, selectivity and fast response time. Herein, we report the synthesis of a hybrid heterostructure comprising SnO nanoparticles supported mesoporous TiO, and the obtained nanocomposite were fabricated over glassy carbon electrode (GCE) for the electrochemical oxidation of vitamin B in pharmaceutical tablets. The designed SnO-TiO/GC modified electrode exhibits well-defined oxidation peak with lowering over-potential and larger signal response compared to the pristine counterparts, and it is mainly due to the formation of abundant active surface layer offered by SnO cocatalyst, and thus significantly enhances the electrochemical surface area. Differential pulse voltammetry (DPV) measurements revealed a sharp increase in the anodic peak current upon addition of increasing concentration of vitamin B. The analytical performance of the modified electrode displayed a wide linear range (0.1-31.4 µM), high selectivity, and excellent sensitivity (759.73 µA mM cm) with low detection limit (35 nM). Thus, the resultant mesoporous hybrid nanocatalyst provides an efficient electrochemical platform for determination of various potential analytes.
电化学法检测水溶性维生素在药物质量控制实验室中得到了广泛的应用，特别是近年来杂化异质结构纳米材料的发展，致力于提高灵敏度、选择性和快速响应时间等重要分析参数。本文报道了一种由负载在介孔 TiO 上的 SnO 纳米粒子组成的杂化异质结构的合成，将所得纳米复合材料制备在玻碳电极（GCE）上，用于药物片剂中维生素 B 的电化学氧化。与原始材料相比，设计的 SnO-TiO/GC 修饰电极具有定义良好的氧化峰，降低了过电势，并且信号响应更大，这主要归因于 SnO 助催化剂提供的丰富活性表面层的形成，从而显著提高了电化学表面积。差分脉冲伏安法（DPV）测量显示，随着维生素 B 浓度的增加，阳极峰电流急剧增加。修饰电极的分析性能显示出宽线性范围（0.1-31.4 μM）、高选择性和优异的灵敏度（759.73 μA mM cm），检测限低（35 nM）。因此，所得介孔杂化纳米催化剂为各种潜在分析物的测定提供了有效的电化学平台。
