日本严重发热伴血小板减少综合征患者外周血中浆母细胞的短暂出现。
Transient Appearance of Plasmablasts in the Peripheral Blood of Japanese Patients With Severe Fever With Thrombocytopenia Syndrome.
机构信息
Department of Hematology, Yamaguchi Grand Medical Center, Yamaguchi University Graduate School of Medicine, Yamaguchi.
Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
出版信息
J Infect Dis. 2019 Jun 5;220(1):23-27. doi: 10.1093/infdis/jiz054.
Atypical lymphocytes in the peripheral blood in patients with severe fever with thrombocytopenia syndrome (SFTS) have not been well examined. In this study, we analyzed counts and characteristics of atypical lymphocytes in 7 patients with SFTS. Atypical lymphocytes resembled plasma cells morphologically and appeared in the peripheral blood of all patients 4-8 days after onset of disease. Among these lymphocytes flow cytometry showed a CD19+CD38+CD138-/+ phenotype, and immunohistochemical staining revealed a CD79a+CD38+CD138-/+CD27+ phenotype. From our observations, atypical lymphocytes transiently that appeared in the peripheral blood during the acute phase of SFTS were considered to be plasmablasts.
在伴有发热伴血小板减少综合征（SFTS）的患者的外周血中，异型淋巴细胞尚未得到很好的检查。在本研究中，我们分析了 7 例 SFTS 患者异型淋巴细胞的计数和特征。异型淋巴细胞在形态上类似于浆细胞，出现在所有患者发病后 4-8 天的外周血中。这些淋巴细胞通过流式细胞术表现为 CD19+CD38+CD138-/+表型，免疫组织化学染色显示 CD79a+CD38+CD138-/+CD27+表型。根据我们的观察，在 SFTS 的急性期短暂出现在外周血中的异型淋巴细胞被认为是浆母细胞。
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