School of Materials Science and Hydrogen Energy, Foshan University, Foshan, Guangdong 528000, China.
Guangdong Key Laboratory for Hydrogen Energy Technologies, Foshan 528000, China.
Langmuir. 2023 Aug 1;39(30):10521-10529. doi: 10.1021/acs.langmuir.3c01005. Epub 2023 Jul 17.
Bacterial adhesion and colonization on material surfaces pose a serious problem for healthcare-associated devices. Cationic amphiphilic polymer brushes are usually used as surface coatings in antibacterial materials to endow an interface with excellent bactericidal efficiency, but they are easily contaminated, which puts a great limitation on their application. Herein, novel antibacterial copolymer brush surfaces containing geminized cationic amphiphilic polymers (pAGC) and thermoresponsive poly(-isopropylacrylamide) polymers (pNIPAm) have been synthesized. Surface functionalization of polymer brushes was investigated by X-ray photoelectron spectroscopy, spectroscopic ellipsometry, atomic force microscopy, and water contact angle measurements. A proportion of AGC and NIPAm units in copolymer brushes has been adjusted to obtain a high-efficiency bactericidal surface with minimal interference to its self-cleaning property. The killing and releasing efficiency of the optimized surface simultaneously reached up to above 80% for both and bacteria, and the bactericidal and self-cleaning abilities are still excellent even after three kill-release cycles. Such a novel copolymer brush system provides innovative guidance for the development of high-efficiency antibacterial materials in biomedical application.
细菌在材料表面的黏附和定殖给与医疗相关的器械带来了严重的问题。阳离子两亲聚合物刷通常被用作抗菌材料的表面涂层，赋予界面优异的杀菌效率，但它们很容易被污染，这极大地限制了它们的应用。在此，合成了含有双阳离子两亲聚合物 (pAGC) 和温敏聚(-异丙基丙烯酰胺) 聚合物 (pNIPAm) 的新型抗菌共聚刷表面。通过 X 射线光电子能谱、光谱椭圆光度法、原子力显微镜和水接触角测量研究了聚合物刷的表面功能化。通过调整共聚物刷中 AGC 和 NIPAm 单元的比例，获得了具有最小自清洁性能干扰的高效杀菌表面。优化表面的杀菌和释放效率对 和 细菌均达到了 80%以上，即使经过三次杀菌-释放循环，杀菌和自清洁能力仍保持优异。这种新型共聚刷体系为生物医学应用中高效抗菌材料的发展提供了创新性的指导。
