German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.
Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Dresden, Germany.
Nat Rev Neurosci. 2019 Apr;20(4):235-245. doi: 10.1038/s41583-019-0120-x.
'Enriched environments' are a key experimental paradigm to decipher how interactions between genes and environment change the structure and function of the brain across the lifespan of an animal. The regulation of adult hippocampal neurogenesis by environmental enrichment is a prime example of this complex interaction. As each animal in an enriched environment will have a slightly different set of experiences that results in downstream differences between individuals, enrichment can be considered not only as an external source of rich stimuli but also to provide the room for individual behaviour that shapes individual patterns of brain plasticity and thus function.
“丰富环境”是一个重要的实验范式，可以用来解析基因与环境之间的相互作用如何改变动物整个生命周期内大脑的结构和功能。环境丰富对成年海马神经发生的调节就是这种复杂相互作用的一个典型例子。由于丰富环境中的每只动物都会有一组略有不同的经历，从而导致个体之间的下游差异，因此丰富环境不仅可以被视为丰富刺激的外部来源，还可以为个体行为提供空间，从而塑造个体大脑可塑性和功能的模式。
