Department of Medicine, University of California, San Francisco, California, USA.
Veterans Affairs Medical Center, San Francisco, California, USA.
Sci Rep. 2019 Feb 5;9(1):1404. doi: 10.1038/s41598-019-38904-0.
The relationship between alcohol consumption and mortality generally exhibits a U-shaped curve. The longevity observed with moderate alcohol consumption may be explained by other confounding factors, and, if such a relationship is present, the mechanism is not well understood. Indeed, the optimal amount of alcohol consumption for health has yet to be determined. Leukocyte telomere length is an emerging quantifiable marker of biological age and health, and a shorter telomere length is a predictor of increased mortality. Because leukocyte telomere length is a quantifiable and objectively measurable biomarker of aging, we sought to identify the amount of alcohol consumption associated with the longest telomere length and least telomere length attrition. Among over 2,000 participants from two distinct cohort studies, we found no pattern of alcohol consumption that was associated with longer telomere length or less telomere length attrition over time. Binge drinking may reduce telomere length. Using telomere length as a marker of age and health, these data fail to demonstrate any benefits of alcohol consumption, even when consumed in moderation.
饮酒与死亡率之间的关系通常呈 U 型曲线。适量饮酒所观察到的长寿可能是由其他混杂因素引起的，而且，如果存在这种关系，其机制尚不清楚。事实上，饮酒对健康的最佳量尚未确定。白细胞端粒长度是生物年龄和健康的新兴可量化标志物，端粒较短是死亡率增加的预测指标。由于白细胞端粒长度是可量化和客观测量的衰老生物标志物，我们试图确定与最长端粒长度和最短端粒长度衰减相关的饮酒量。在来自两个不同队列研究的 2000 多名参与者中，我们没有发现任何与端粒长度较长或端粒长度随时间衰减较少相关的饮酒模式。狂饮可能会缩短端粒长度。使用端粒长度作为年龄和健康的标志物，这些数据未能证明饮酒有任何益处，即使适量饮酒也是如此。
