Igarashi Nozomi, Sawamura Hiromasa, Kaburaki Toshikatsu, Aihara Makoto
Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Neuroophthalmology. 2018 May 23;43(1):36-42. doi: 10.1080/01658107.2018.1460761. eCollection 2019 Feb.
A 73-year-old female with a past medical history of breast cancer, who 10 years earlier experienced complete remission, complained of bilateral visual field disturbances and photopsia, 2 months prior. Tumour recurrence and metastatic lesions were not found during the medical examination, but antibodies against recoverin were detected in her serum. Despite immunosuppressive treatment with prednisolone and plasmapheresis, rapid and diffuse degeneration of the patient's photoreceptors and deterioration of her visual field were observed. This is a rare case of cancer-associated retinopathy with a long interval (10 years) between the diagnosis of the malignancy and visual loss.
一名73岁女性，既往有乳腺癌病史，10年前病情完全缓解，2个月前出现双侧视野障碍和闪光感。体格检查未发现肿瘤复发及转移病灶，但血清中检测到抗恢复蛋白抗体。尽管使用泼尼松龙进行免疫抑制治疗及血浆置换，仍观察到患者光感受器迅速弥漫性退变及视野恶化。这是一例罕见的癌症相关性视网膜病变，恶性肿瘤诊断与视力丧失之间间隔时间较长（10年）。
