两名耐药性癫痫患儿接受大脑半球切除术后的纵向脑功能和结构连接变化
Longitudinal brain functional and structural connectivity changes after hemispherotomy in two pediatric patients with drug-resistant epilepsy.
作者信息
Li Yongxin, Wang Ya, Tan Zhen, Chen Qian, Huang Wenhua
机构信息
Guangdong Provincial Key Laboratory of Medical Biomechanics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Department of Pediatric Neurosurgery, Shenzhen Children's Hospital, Shenzhen, China.
出版信息
Epilepsy Behav Case Rep. 2018 Nov 24;11:58-66. doi: 10.1016/j.ebcr.2018.11.003. eCollection 2019.
The main focus of the present study was to explore the longitudinal changes in the brain executive control system and default mode network after hemispherotomy. Resting-state functional magnetic resonance imaging and diffusion tensor imaging were collected in two children with drug-resistnt epilepsy underwent hemispherotomy. Two patients with different curative effects showed different trajectories of brain connectivity after surgery. The failed hemispherotomy might be due to the fact that the synchrony of epileptic neurons in both hemispheres is preserved by residual neural pathways. Loss of interhemispheric correlations with increased intrahemispheric correlations can be considered as neural marker for evaluating the success of hemispherotomy.
本研究的主要重点是探讨大脑半球切除术后脑执行控制系统和默认模式网络的纵向变化。对两名接受大脑半球切除术的耐药性癫痫患儿进行了静息态功能磁共振成像和弥散张量成像检查。两名疗效不同的患者术后大脑连接轨迹不同。大脑半球切除术失败可能是由于残余神经通路保留了双侧半球癫痫神经元的同步性。半球间相关性丧失伴半球内相关性增加可被视为评估大脑半球切除术成功与否的神经标志物。
Zotero 插件