Pfaendler Krista S, Randall Leslie M
University of California Irvine Medical Center, Orange, CA 92868, United States.
Gynecol Oncol Rep. 2019 Jan 18;27:65-68. doi: 10.1016/j.gore.2019.01.004. eCollection 2019 Feb.
Undifferentiated endometrial carcinoma, a rare histopathologic diagnosis, has a poor prognosis with high risk of progression during or shortly after completion of adjuvant treatment. We present two cases of undifferentiated endometrial carcinoma: one in a postmenopausal female who experienced recurrent disease immediately after completion of adjuvant treatment and one in a premenopausal female who experienced disease progression while receiving adjuvant treatment. These cases exemplify the aggressive behavior of undifferentiated endometrial carcinoma and suggest the need for a more effective treatment in the upfront setting than the current standard of care for endometrioid endometrial adenocarcinoma.
未分化子宫内膜癌是一种罕见的组织病理学诊断，预后较差，在辅助治疗期间或完成后不久有很高的进展风险。我们报告两例未分化子宫内膜癌病例：一例为绝经后女性，在辅助治疗完成后立即出现疾病复发；另一例为绝经前女性，在接受辅助治疗期间出现疾病进展。这些病例例证了未分化子宫内膜癌的侵袭性，并表明在初始治疗中需要一种比目前子宫内膜样腺癌的标准治疗更有效的治疗方法。
