Wang Ying, Zheng Yu-Tong, Zhang Ling, Cao Xue-Quan, Lin Zhu, Liu Hong-Yu, Hu Qiong-Ying
The Taizhou Central Hospital (Taizhou University Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, China.
Front Oncol. 2024 Nov 22;14:1440246. doi: 10.3389/fonc.2024.1440246. eCollection 2024.
Uterine corpus endometrial carcinoma, one of the three most frequent cancers of the female reproductive system, primarily affects women who are perimenopausal or postmenopausal. Moreover, it is an epithelial cancer that develops in the endometrium, which is classified as either estrogen-dependent (type I) or non-estrogen-dependent (type II). Non-estrogen-dependent endometrial cancers include plasma cell carcinoma and undifferentiated/dedifferentiated endometrial carcinoma. Undifferentiated endometrial carcinoma is a rare but aggressive endometrial epithelial cancer that lacks any histologic differentiation and is classified as a high-grade endometrial cancer. This case presents that a patient had uterine corpus endometrial carcinoma during perimenopausal hormone therapy, and the patient was treated with sequential estrogen-progestin treatment for 3 years. During that period, she did not undergo a follow-up examination for the last 2 years due to the pandemic. Undifferentiated endometrial carcinoma is a special type of endometrial cancer that is not hormone-dependent, and whether the occurrence of this case is related to perimenopausal hormone therapy needs to be verified by more evidence-based clinical cases and further studies.
子宫体子宫内膜癌是女性生殖系统最常见的三种癌症之一，主要影响围绝经期或绝经后的女性。此外，它是一种发生于子宫内膜的上皮性癌症，可分为雌激素依赖型（I型）或非雌激素依赖型（II型）。非雌激素依赖型子宫内膜癌包括浆细胞癌和未分化/去分化子宫内膜癌。未分化子宫内膜癌是一种罕见但侵袭性强的子宫内膜上皮性癌症，缺乏任何组织学分化，被归类为高级别子宫内膜癌。本病例介绍了一名患者在围绝经期激素治疗期间患子宫体子宫内膜癌，该患者接受序贯雌激素 - 孕激素治疗3年。在此期间，由于疫情，她在最后2年未进行随访检查。未分化子宫内膜癌是一种特殊类型的非激素依赖型子宫内膜癌，该病例的发生是否与围绝经期激素治疗有关，需要更多基于证据的临床病例和进一步研究来证实。
