Department of Medicine, Division of Neurology,Dalhousie University,Halifax, Nova Scotia,Canada.
Department of Neurology,Memorial University of Newfoundland,St. John's, Newfoundland,Canada.
Can J Neurol Sci. 2019 Mar;46(2):243-247. doi: 10.1017/cjn.2018.389. Epub 2019 Feb 6.
Lewis-Sumner syndrome (LSS) is a demyelinating peripheral neuropathy described in 1982.
We reviewed the charts of nine LSS patients in neurological care for their symptoms, response to different treatment regimens, and pattern of nerve involvement.
One patient had an Adie's pupil. Every patient studied had median nerve involvement. Seven of nine patients required intravenous immunoglobulin (IVIg) therapy and all showed improvement with IVIg. Four of nine patients received oral steroid therapy and had some improvement. Two of nine patients received azathioprine to little effect. Two of nine patients experienced significant trauma while receiving neurological follow-up and their symptoms worsened to a clinically significant degree afterward.
We noticed a possible association between trauma and symptom severity in cases of LSS with preexisting neurological follow-up. We hypothesize that physical trauma exacerbates LSS. To our knowledge, this is an unreported phenomenon.
刘易斯-萨姆纳综合征（LSS）是一种脱髓鞘周围神经病，于 1982 年描述。
我们回顾了在神经科护理中接受治疗的 9 例 LSS 患者的病历，以了解他们的症状、对不同治疗方案的反应以及神经受累模式。
1 例患者有阿狄森瞳孔。所有研究的患者均有正中神经受累。9 例患者中有 7 例需要静脉注射免疫球蛋白（IVIg）治疗，所有患者均在 IVIg 治疗后得到改善。9 例患者中有 4 例接受了口服类固醇治疗，有一定程度的改善。9 例患者中有 2 例接受了硫唑嘌呤治疗，但效果不大。9 例患者中有 2 例在接受神经科随访时遭受了严重创伤，此后症状明显恶化。
我们注意到在存在神经科随访的 LSS 病例中，创伤与症状严重程度之间可能存在关联。我们假设身体创伤会使 LSS 恶化。据我们所知，这是一种未被报道的现象。
