Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, China.
Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts.
Clin Endocrinol (Oxf). 2019 May;90(5):711-718. doi: 10.1111/cen.13945. Epub 2019 Mar 7.
This study aims to evaluate the association of serum iodine concentration (SIC) with urinary iodine concentration (UIC) and thyroid function in pregnant women, as well as to provide the reference range of SIC of pregnant women in iodine-sufficiency area.
Pregnant women were enrolled in the Department of Obstetrics, Tanggu Maternity Hospital, Tianjin from March 2016 to May 2017. Fasting venous blood and spot urine samples were collected. Serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), thyroglobulin (Tg), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), UIC and SIC were measured.
One thousand and ninety-nine participants were included in this study. The median UIC was 156 μg/L. The median SIC was 108 μg/L, and the 95% reference interval for SIC was 65.6-164.7 μg/L. SIC was positively correlated with UIC (r = 0.12, P < 0.001), FT3 (r = 0.23, P < 0.001), and FT4 (r = 0.50, P < 0.001) and was inversely correlated with TSH (r = -0.14, P < 0.001). Pregnant women with a SIC < 79.9 μg/L had a higher risk of hypothyroxinemia compared to those with higher SIC (OR = 2.44, 95% CI: 1.31-4.75). Those having SIC > 138.5 μg/L were more likely to have thyrotoxicosis than those with lower SIC values (OR = 13.52, 95% CI: 4.21-43.36).
Serum iodine level is associated with UIC and thyroid function in pregnant women. Low SIC was associated with increased risk for iodine deficiency and hypothyroxinemia, while high SIC was related to excess and thyrotoxicosis.
本研究旨在评估血清碘浓度（SIC）与尿碘浓度（UIC）和孕妇甲状腺功能之间的关系，并为碘充足地区孕妇的 SIC 参考范围提供依据。
2016 年 3 月至 2017 年 5 月，选取天津市塘沽妇产医院产科就诊的孕妇，采集空腹静脉血和随机尿标本，检测血清游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、促甲状腺激素（TSH）、甲状腺球蛋白（Tg）、甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TgAb）、UIC 和 SIC。
本研究共纳入 1099 名孕妇。UIC 的中位数为 156μg/L，SIC 的中位数为 108μg/L，SIC 的 95%参考区间为 65.6-164.7μg/L。SIC 与 UIC 呈正相关（r=0.12，P<0.001），与 FT3（r=0.23，P<0.001）和 FT4（r=0.50，P<0.001）呈正相关，与 TSH（r=-0.14，P<0.001）呈负相关。与 SIC≥79.9μg/L 的孕妇相比，SIC<79.9μg/L 的孕妇发生低甲状腺素血症的风险更高（OR=2.44，95%CI：1.31-4.75）。SIC>138.5μg/L 的孕妇发生甲状腺功能亢进的风险高于 SIC 较低者（OR=13.52，95%CI：4.21-43.36）。
孕妇血清碘水平与 UIC 和甲状腺功能有关。低 SIC 与碘缺乏和低甲状腺素血症风险增加相关，而高 SIC 与碘过量和甲状腺功能亢进相关。
