快速的任务相关调节对鼠类嗅觉球的影响。

Sensory and Behavioural Neuroscience Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.

Neurophysiology of Behaviour Laboratory, The Francis Crick Institute, London, United Kingdom.

Elife. 2019 Feb 6;8:e43558. doi: 10.7554/eLife.43558.

Adapting neural representation to rapidly changing behavioural demands is a key challenge for the nervous system. Here, we demonstrate that the output of the primary olfactory area of the mouse, the olfactory bulb, is already a target of dynamic and reproducible modulation. The modulation depends on the stimulus tuning of a given neuron, making olfactory responses more discriminable through selective amplification in a demand-specific way.

使神经表示适应快速变化的行为需求是神经系统面临的主要挑战。在这里，我们证明了小鼠主要嗅觉区域（嗅球）的输出已经是动态和可重复调节的目标。这种调节取决于给定神经元的刺激调谐，通过以特定于需求的方式进行选择性放大，使嗅觉反应更具可辨别性。