Xia Shujun, Ren Xinping, Ni Zhongxin, Zhan Weiwei
Ultrasound Department, Rui Jin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ultrasound Q. 2019 Jun;35(2):147-152. doi: 10.1097/RUQ.0000000000000399.
The aim of our study was to investigate the efficiency and feasibility of shear-wave elastography (sound touch elastography [STE], sound touch quantification [STQ]) compared with transient elastography (FibroScan) assessment in noninvasively and quantitatively identifying the degree of liver fibrosis. A total of 158 patients with chronic hepatitis B were included, and all accepted STE, STQ, and FibroScan assessments. Young's modulus (kPa) of STE, STQ, and FibroScan were evaluated, and the diagnostic performance of the 3 techniques on liver fibrosis stage was compared. The final diagnosis was based on histological findings from liver biopsy. Of all these patients, 36 patients were categorized as G/S < 2, and 122 were as G/S ≥ 2 according to Scheuer G/S scoring system. STEmean and STQmean measurements were positively correlated with liver fibrosis stage with high correlation (r = 0.852 and r = 0.803, respectively). Receiver operating characteristic analysis of STE, STQ, and FibroScan revealed that the areas under the curve of STE and STQ were markedly increased compared with that of FibroScan when differentiating early stage of liver fibrosis (S1, S2). It was concluded that shear-wave elastography (STE, STQ, and FibroScan) performs well in evaluation of liver fibrosis in patients with chronic hepatitis B, and the efficacies of STE and STQ are better than that of FibroScan.
我们研究的目的是探讨与瞬时弹性成像（FibroScan）评估相比，剪切波弹性成像（声触诊组织定量技术[STE]、声触诊定量[STQ]）在非侵入性定量识别肝纤维化程度方面的有效性和可行性。共纳入158例慢性乙型肝炎患者，所有患者均接受了STE、STQ和FibroScan评估。评估了STE、STQ和FibroScan的杨氏模量（kPa），并比较了这3种技术对肝纤维化分期的诊断性能。最终诊断基于肝活检的组织学结果。根据Scheuer G/S评分系统，所有这些患者中，36例患者分类为G/S<2，122例患者分类为G/S≥2。STEmean和STQmean测量值与肝纤维化分期呈高度正相关（r分别为0.852和0.803）。STE、STQ和FibroScan的受试者工作特征分析显示，在区分肝纤维化早期（S1、S2）时，STE和STQ的曲线下面积与FibroScan相比显著增加。得出结论，剪切波弹性成像（STE、STQ和FibroScan）在评估慢性乙型肝炎患者肝纤维化方面表现良好，且STE和STQ的有效性优于FibroScan。
