Hoffman Robert M
AntiCancer, Inc., San Diego, CA, USA.
Department of Surgery, University of California, San Diego, CA, USA.
Methods Mol Biol. 2019;1866:267-271. doi: 10.1007/978-1-4939-8796-2_20.
Methionine (MET) dependence is a cancer-specific metabolic abnormality that is due to MET overuse for aberrant transmethylation reactions. [C]-MET is very useful for positron-emission tomography (PET) due to MET overuse in malignant tumors. Many benefits of MET-PET have been demonstrated. MET-PET can differentiate recurrent glioma and necrosis. [C]-MET-PET can also predict prognosis in gliomas better than [F]-FDG PET. [C]-MET-PET is better than MRI for predicting survival in low-grade glioma (LGG). MET-PET has greater specificity for detecting residual tumor after surgery than MRI.
甲硫氨酸（MET）依赖性是一种癌症特异性代谢异常，这是由于MET在异常转甲基化反应中的过度使用所致。由于恶性肿瘤中MET的过度使用，[C]-MET对正电子发射断层扫描（PET）非常有用。MET-PET的许多益处已得到证实。MET-PET可以区分复发性胶质瘤和坏死。[C]-MET-PET在预测胶质瘤预后方面也比[F]-FDG PET更好。在预测低级别胶质瘤（LGG）的生存期方面，[C]-MET-PET比MRI更好。MET-PET在检测术后残留肿瘤方面比MRI具有更高的特异性。
