Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
Department of Oral and Maxillofacial Surgery, King Fahad Medical City, Riyadh, Saudi Arabia.
J Oral Pathol Med. 2019 May;48(5):345-350. doi: 10.1111/jop.12837. Epub 2019 Feb 21.
The small signalling molecule nitric oxide (NO) has been postulated to have a mediator role in the pathogenesis of several diseases including oral lichen planus (OLP). This systematic review aimed to quantify the existing literature and assess the association of NO and OLP.
The focused question being addressed was "Is there an association between nitric oxide and OLP?" PubMed, EMBASE, Scopus, and Web of Science, and grey literature from January 1990 to August 2018 were searched. Two independent reviewers performed the study selection using specified eligibility criteria.
Seven studies that met the eligibility criteria were included. All of these were case-control studies and 151 patients with OLP were evaluated (mostly females), with an age ranged from 20 to 75 years. The included studies showed a significant higher NO levels in OLP patients compared to the healthy controls, with two studies demonstrated a higher NO levels in erosive OLP compared to non-erosive OLP.
These findings support that an association exists between higher NO concentration and OLP. However, larger high-quality studies with refined methodological design are needed to confirm the role of NO in the aetiology and pathogenesis of OLP.
小分子信号分子一氧化氮（NO）被认为在几种疾病的发病机制中具有中介作用，包括口腔扁平苔藓（OLP）。本系统评价旨在量化现有文献并评估 NO 与 OLP 的相关性。
关注的焦点问题是“NO 与 OLP 之间是否存在关联？” 检索了 1990 年 1 月至 2018 年 8 月的 PubMed、EMBASE、Scopus 和 Web of Science 以及灰色文献。两名独立的审查员使用指定的纳入标准进行了研究选择。
符合纳入标准的有 7 项研究。这些研究均为病例对照研究，共评估了 151 例 OLP 患者（主要为女性），年龄在 20 至 75 岁之间。纳入的研究表明 OLP 患者的 NO 水平明显高于健康对照组，有两项研究表明糜烂性 OLP 患者的 NO 水平高于非糜烂性 OLP。
这些发现支持 NO 浓度与 OLP 之间存在关联。然而，需要更多设计精细的高质量大型研究来证实 NO 在 OLP 的病因和发病机制中的作用。
