Humberto Janaina Silva Martins, Pavanin Jefferson Veronezi, Rocha Maria José Alves da, Motta Ana Carolina Fragoso
Universidade de São Paulo - USP, School of Dentistry of Ribeirão Preto, Department of Morphology, Physiology, and Basic Pathology, Ribeirão Preto, SP, Brazil.
Universidade de São Paulo - USP, School of Dentistry of Ribeirão Preto, Department of Stomatology, Ribeirão Preto, SP, Brazil.
Braz Oral Res. 2018 Aug 13;32:e82. doi: 10.1590/1807-3107bor-2018.vol32.0082.
The etiopathogenesis of oral lichen planus (OLP) is still not fully elucidated, and it is believed that its development could involve a neuro-immune-endocrine profile. This systematic review investigated the relationship between cytokines, cortisol, and nitric oxide (NO) in the saliva of OLP patients. An electronic search was conducted in Pubmed/Medline, Scopus, LIVIVO, and Web of Science databases with no restriction of language to identify studies published up to December 2017. Data extraction was performed using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. A total of 140 articles were retrieved, and 32 articles fulfilled the inclusion criteria (cytokines = 17; cortisol = 9; NO = 6). The most studied cytokines in the saliva of OLP patients were interleukins IL-4, IL-6, IL-8, IFN-ү, and TNF-α, which were higher in OLP patients than in healthy controls (HC). Salivary cortisol was found to be higher in OLP than in HC in most (55.5%) of the selected studies, and all studies related to NO found higher levels of this marker in OLP than in HC. Despite controversial results, our review suggests that OLP patients have an increased inflammatory response, as indicated by the proinflammatory profile of salivary cytokines. In addition, we conclude that salivary cytokine and NO measurements may have significant diagnostic and prognostic potential for monitoring disease activity and therapeutic responses in OLP.
口腔扁平苔藓（OLP）的发病机制尚未完全阐明，人们认为其发病可能涉及神经 - 免疫 - 内分泌特征。本系统评价研究了OLP患者唾液中细胞因子、皮质醇和一氧化氮（NO）之间的关系。在Pubmed/Medline、Scopus、LIVIVO和Web of Science数据库中进行了电子检索，不限语言，以识别截至2017年12月发表的研究。使用系统评价和Meta分析的首选报告项目（PRISMA）指南进行数据提取。共检索到140篇文章，32篇文章符合纳入标准（细胞因子 = 17篇；皮质醇 = 9篇；NO = 6篇）。OLP患者唾液中研究最多的细胞因子是白细胞介素IL - 4、IL - 6、IL - 8、IFN - γ和TNF - α，OLP患者这些细胞因子水平高于健康对照（HC）。在大多数（55.5%）入选研究中，发现OLP患者唾液皮质醇高于HC，所有与NO相关的研究均发现OLP患者该标志物水平高于HC。尽管结果存在争议，但我们的综述表明，如唾液细胞因子的促炎特征所示，OLP患者的炎症反应增强。此外，我们得出结论，唾液细胞因子和NO检测对于监测OLP的疾病活动和治疗反应可能具有显著的诊断和预后潜力。
