Department of Oral Medicine, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, 210029 Jiangsu, China.
Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, 210029 Jiangsu, China.
Oxid Med Cell Longev. 2021 Sep 27;2021:9914652. doi: 10.1155/2021/9914652. eCollection 2021.
Oral lichen planus (OLP) is a relatively common chronic inflammatory disease of unknown etiology, which might be caused by oxidative stress and impaired antioxidant defense.
To systematically investigate the markers of oxidative stress and antioxidant systems in the saliva and blood from OLP patients and healthy controls.
The PubMed, Cochrane Library, and Embase were systematically queried to collect data from studies in which oxidative stress/antioxidant markers from OLP and healthy subjects had been evaluated until March 10, 2021.
A total of 28 studies fulfilled inclusion criteria, and 25 of them, having 849 OLP patients and 1,052 control subjects and analyzing 12 oxidative stress and antioxidant state marker levels, were subjected to meta-analysis. We found a significant decrease in total antioxidant capacity (TAC) and uric acid (UA) and a significant increase in malondialdehyde (MDA) and nitric oxide (NO) levels in the saliva and serum/plasma of OLP patients. Moreover, a significant elevation of 8-hydroxy-deoxyguanosine (8-OHdG) and advanced oxidation protein product (AOOP) level and a decrease in vitamin C were also observed in the saliva of the OLP group. In contrast, salivary vitamin A, zinc, glutathione peroxidase (GPx), vitamin E, and nitrite were not significantly different between the two groups. In single studies, markers of oxidative stresses such as superoxide dismutase (SOD) and 8-isoprostanelevels were elevated in OLP, and antioxidant parameters such as glutathione (GSH) and total protein (TP) levels were dysregulated.
This meta-analysis helps to clarify the profile of oxidative stress and antioxidant state markers in OLP patients although existing evidence is rather heterogeneous and many studies are affected by several limitations. Larger and more standardized studies are warranted to ascertain whether these markers are potential causes or effects of OLP and whether antioxidant therapy improving oxidative stress will be useful.
口腔扁平苔藓（OLP）是一种相对常见的病因不明的慢性炎症性疾病，可能由氧化应激和抗氧化防御受损引起。
系统研究 OLP 患者和健康对照者唾液和血液中的氧化应激和抗氧化系统标志物。
系统检索 PubMed、Cochrane 图书馆和 Embase，以收集截至 2021 年 3 月 10 日评估 OLP 和健康受试者氧化应激/抗氧化标志物的研究数据。
共有 28 项研究符合纳入标准，其中 25 项研究（共 849 名 OLP 患者和 1052 名对照者，分析了 12 种氧化应激和抗氧化状态标志物水平）进行了荟萃分析。我们发现 OLP 患者唾液和血清/血浆中的总抗氧化能力（TAC）和尿酸（UA）水平显著降低，丙二醛（MDA）和一氧化氮（NO）水平显著升高。此外，还观察到 OLP 组唾液中的 8-羟基脱氧鸟苷（8-OHdG）和高级氧化蛋白产物（AOOP）水平显著升高，维生素 C 水平降低。相比之下，两组唾液中的维生素 A、锌、谷胱甘肽过氧化物酶（GPx）、维生素 E 和亚硝酸盐水平无显著差异。在单项研究中，超氧化物歧化酶（SOD）等氧化应激标志物和 8-异前列腺素水平升高，而谷胱甘肽（GSH）和总蛋白（TP）等抗氧化参数失调。
尽管现有证据存在较大异质性且许多研究受到多种局限性的影响，但本荟萃分析有助于阐明 OLP 患者氧化应激和抗氧化状态标志物的特征。需要更大和更标准化的研究来确定这些标志物是否是 OLP 的潜在原因或结果，以及改善氧化应激的抗氧化治疗是否有用。
