Supramolecular Chemistry Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 S4, 9000, Ghent, Belgium.
Organic and Biomimetic Chemistry Research Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 S4, 9000, Ghent, Belgium.
Macromol Rapid Commun. 2019 May;40(10):e1800900. doi: 10.1002/marc.201800900. Epub 2019 Feb 6.
Thermoresponsive polymeric materials are important building blocks for smart materials. In this work, the transformation of dsDNA into a thermoresponsive polymer is reported by intercalation of short, oligoethylene-glycol-modified proflavine intercalators. The thermoresponsiveness of the dsDNA-intercalator complex originates from the heating-induced dehydration of the ethylene glycol side chains, which leads to aggregation of the intercalated dsDNA. This work demonstrates the possibility of designing small-molecule intercalators to prepare thermoresponsive dsDNA complexes with tunable lower critical solution temperature behavior.
温敏性聚合物材料是智能材料的重要组成部分。在这项工作中，通过短的、聚乙二醇修饰的吖啶黄素嵌入剂的嵌入，将双链 DNA 转化为温敏性聚合物。双链 DNA-嵌入剂复合物的温敏性源于乙二醇侧链的加热诱导去水，导致嵌入的双链 DNA 聚集。这项工作证明了设计小分子嵌入剂来制备具有可调下临界溶液温度行为的温敏性双链 DNA 复合物的可能性。
