1School of Medicine, University of Western Australia, Perth, Western Australia, Australia.
2School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
Am J Respir Crit Care Med. 2019 Aug 15;200(4):462-470. doi: 10.1164/rccm.201807-1332OC.
tobacco exposure is associated with reduced lung function from infancy. Antioxidant enzymes from the glutathione -transferase (GST) family may protect against these lung function deficits. To assess the long-term effect of smoke exposure on lung function into adulthood, and to assess whether and active genotypes have long-term protective effects on lung function. In this longitudinal study based on a general population ( = 253), lung function was measured during infancy and at 6, 11, 18, and 24 years. and genotype was analyzed in a subgroup ( = 179). Lung function was assessed longitudinally from 6 to 24 years ( = 199). Exposure to maternal tobacco was associated with lower FEV and FVC longitudinally from 6 to 24 years (mean difference, -3.87% predicted, = 0.021; -3.35% predicted, = 0.035, respectively). Among those homozygous for the null genotype, tobacco exposure was associated with lower FEV and FVC compared with those with no tobacco exposure (mean difference, -6.2% predicted, = 0.01; -4.7% predicted, = 0.043, respectively). For those with active genotype, there was no difference in lung function whether exposed to maternal tobacco or not. tobacco exposure was associated with deficits in lung function among those with both null and -active genotypes. Certain GST genotypes may have protective effects against the long-term deficits in lung function associated with tobacco exposure. This offers potential preventative targets in antioxidant pathways for at-risk infants of smoking mothers.
烟草暴露与婴儿期起的肺功能降低有关。谷胱甘肽转移酶 (GST) 家族的抗氧化酶可能有助于预防这些肺功能缺陷。为了评估吸烟暴露对成年后肺功能的长期影响，并评估 和 活性基因型是否对肺功能具有长期的保护作用。在这项基于普通人群的纵向研究中（ = 253），在婴儿期以及 6、11、18 和 24 岁时测量肺功能。在一个亚组中（ = 179）分析 和 基因型。从 6 岁到 24 岁，肺功能进行了纵向评估（ = 199）。从 6 岁到 24 岁，母亲吸烟的暴露与 FEV 和 FVC 的纵向降低有关（平均差异，-3.87%预测值， = 0.021；-3.35%预测值， = 0.035，分别）。在纯合子缺失基因型中，与无烟草暴露的个体相比，母亲吸烟的暴露与 FEV 和 FVC 的降低有关（平均差异，-6.2%预测值， = 0.01；-4.7%预测值， = 0.043，分别）。对于具有 活性基因型的个体，无论是否暴露于母亲的 烟草，肺功能均无差异。在具有 缺失和 活性基因型的个体中，烟草暴露与肺功能缺陷有关。某些 GST 基因型可能对与吸烟暴露相关的肺功能长期缺陷具有保护作用。这为吸烟母亲的高危婴儿提供了抗氧化途径的潜在预防靶点。
