Bozkurt Erdinç, Çakır Burçin, Çelik Erkan, Doğan Emine, Uçak Turgay, Alagöz Gürsoy
Sakarya University Education and Research Hospital, Sakarya, Turkey.
Erzincan University Education and Research Hospital, Erzincan, Turkey.
Arq Bras Oftalmol. 2019 Mar-Apr;82(2):136-140. doi: 10.5935/0004-2749.20190021. Epub 2019 Jan 10.
We aimed to compare the aqueous humor total oxidant status, total antioxidant capacity, and levels of interleukin-6 and vascular endothelial growth factor between patients with diabetic retinopathy and controls and to correlate these levels with the DR status.
Patients who underwent cataract surgery were enrolled. The first group (control group) comprised patients without diabetes; the second group comprised diabetic patients without retinopathy; the third group comprised patients with nonproliferative diabetic retinopathy; and the fourth group comprised patients with proliferative diabetic retinopathy. All patients underwent full ophthalmologic examination before cataract surgery. Prior to surgery, samples of aqueous humor sampling were obtained and stored at -80 °C. Total antioxidant capacity, total oxidant status, and levels interleukin-6 and vascular endothelial growth factor were investigated in these samples and correlated with diabetic retinopathy status.
This study analyzed 86 pairs of eyes of 86 patients. All groups were statistically similar in age and sex, but the total antioxidant capacity was lowest in patients with proliferative diabetic retinopathy. Moreover, the total oxidant status and levels of vascular endothelial growth factor and interleukin-6 were found to slightly increase according to the retinopathy status.
Oxidative stress, interleukin-6, and vascular endothelial growth factor in the aqueous humor seem to play important roles in the pathogenesis of diabetic retinopathy, especially in the proliferative type.
我们旨在比较糖尿病视网膜病变患者与对照组房水的总氧化状态、总抗氧化能力、白细胞介素 -6 和血管内皮生长因子水平，并将这些水平与糖尿病视网膜病变状态相关联。
纳入接受白内障手术的患者。第一组（对照组）为无糖尿病患者；第二组为无视网膜病变的糖尿病患者；第三组为非增殖性糖尿病视网膜病变患者；第四组为增殖性糖尿病视网膜病变患者。所有患者在白内障手术前均接受全面眼科检查。手术前，采集房水样本并储存于 -80°C。对这些样本进行总抗氧化能力、总氧化状态以及白细胞介素 -6 和血管内皮生长因子水平的检测，并与糖尿病视网膜病变状态相关联。
本研究分析了 86 例患者的 86 对眼睛。所有组在年龄和性别上具有统计学相似性，但增殖性糖尿病视网膜病变患者的总抗氧化能力最低。此外，发现总氧化状态以及血管内皮生长因子和白细胞介素 -6 水平随视网膜病变状态略有升高。
房水中的氧化应激、白细胞介素 -6 和血管内皮生长因子似乎在糖尿病视网膜病变的发病机制中起重要作用，尤其是在增殖型中。
