Movement Disorders Section, Department of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Hertie-Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, Tübingen, Germany.
Mov Disord. 2019 Apr;34(4):564-568. doi: 10.1002/mds.27620. Epub 2019 Feb 6.
The pattern and role of microglial activation in multiple system atrophy is largely unclear. The objective of this study was to use C-PK11195 PET to determine the extent and correlation of activated microglia with clinical parameters in MSA patients.
Fourteen patients with the parkinsonian phenotype of MSA (MSA-P) with a mean disease duration of 2.9 years (range 2-5 years) were examined with C-PK11195 PET and compared with 10 healthy controls.
Patients with the parkinsonian phenotype of MSA showed a significant (P ≤ 0.01) mean increase in binding potentials compared with healthy controls in the caudate nucleus, putamen, pallidum, precentral gyrus, orbitofrontal cortex, presubgenual anterior cingulate cortex, and the superior parietal gyrus. No correlations between binding potentials and clinical parameters were found.
In early clinical stages of the parkinsonian phenotype of MSA, there is widespread microglial activation as a marker of neuroinflammatory changes without correlation to clinical parameters in our patient population. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
多系统萎缩中微胶质细胞激活的模式和作用在很大程度上尚不清楚。本研究的目的是使用 C-PK11195 PET 来确定 MSA 患者中激活的小胶质细胞与临床参数的程度和相关性。
14 名具有多系统萎缩帕金森表型（MSA-P）的患者（平均病程 2.9 年，范围 2-5 年）接受 C-PK11195 PET 检查，并与 10 名健康对照者进行比较。
MSA-P 患者与健康对照组相比，尾状核、壳核、苍白球、中央前回、眶额皮质、前扣带回皮质下和顶上回的结合势均显著增加（P≤0.01）。结合势与临床参数之间无相关性。
在 MSA-P 的早期临床阶段，存在广泛的小胶质细胞激活，作为神经炎症变化的标志物，与我们患者群体的临床参数无相关性。© 2019 作者。运动障碍由 Wiley Periodicals, Inc. 代表国际帕金森病和运动障碍协会出版。
