第 2 组固有淋巴细胞在人类呼吸疾病中的作用。
Group 2 Innate Lymphoid Cells in Human Respiratory Disorders.
机构信息
Department of Cell Biology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
出版信息
J Innate Immun. 2020;12(1):47-62. doi: 10.1159/000496212. Epub 2019 Feb 6.
Recent studies using animal models have generated profound insight into the functions of various subsets of innate lymphoid cells (ILCs). The group 2 ILC subset (ILC2) has been implicated in tissue homeostasis, defense responses against parasites, tissue repair, and immunopathology associated with type-2 immunity. In addition, progress has also been made in translating these findings from animal studies into a context of human immunity. Importantly, recent observations strongly support a role for ILC2s in several diseases of the human respiratory system. However, many aspects of human ILC2 biology are still unclear, including how these cells develop and which signals control their activity. As a result, the exact role played by ILCs in human health and disease remains poorly understood. Here, we summarize our current understanding of human ILC2 biology and focus on their potential involvement in various human respiratory disorders.
最近使用动物模型的研究深入揭示了各种固有淋巴细胞亚群（ILC）的功能。 2 型固有淋巴细胞（ILC2）亚群已被牵涉到组织内稳态、对抗寄生虫的防御反应、组织修复以及与 2 型免疫相关的免疫病理学中。此外，这些发现也从动物研究逐渐被转化到人类免疫的背景中。重要的是，最近的观察结果强烈支持 ILC2 在人类呼吸系统的几种疾病中发挥作用。然而，人类 ILC2 生物学的许多方面仍然不清楚，包括这些细胞如何发育以及哪些信号控制它们的活性。因此，ILC 在人类健康和疾病中的确切作用仍知之甚少。在这里，我们总结了我们对人类 ILC2 生物学的理解，并重点介绍了它们在各种人类呼吸障碍中的潜在作用。
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